Modeling monoclonal antibodies with patchy particles

  • Michela Ronti (Autor*in)

Aktivität: VorträgePosterpräsentationScience to Science


Combining direct analytical theoretical calculations and canonical Monte Carlo simulations we have studied the solution behavior of a monoclonal antibody over a large concentration range, in order to investigate the consequence and nature of the protein-protein interactions. We have used a simple colloidal patchy model, in order to obtain analitically the thermodynamic properties (through the Wertheim theory [1]) and to obtain the connectivity properties (using the Hyperbranched Polymers Theory [2]). We have also used Montecarlo simulations to verify the results predicted theoretically. We are currently working to better understand the protein-protein interactions and to study analytically the structure factor. Our final aim is a mapping of the numerical and theoretical results with the experimental results of the group of Lund University. [1] M.S. Wertheim, J. Stat. Phys. 35, 19 and 35 (1984) [2] M. Rubinstein and R.H. Colby in Polymer Physics (Oxford University Press, Oxford, 2003)
EreignistitelFisMat 2015
OrtPalermo, ItalienAuf Karte anzeigen