Bernhard Keppler

Publikationen

Publikationen pro Jahr 2000 2005 2008 2010 2011 2012 2014 2015 2016 2017 2018 2019 2023 2025

• 534 Artikel
• 56 Beitrag in Konferenzband
• 42 Meeting Abstract/Conference Paper
• 26 Review
• 30 Mehr
  • 11 Beitrag in Buch/Sammelband
  • 10 Paper
  • 4 Patentschrift
  • 3 Correction
  • 1 Editorial
  • 1 Working Paper

Publikationen pro Jahr

Publikationen pro Jahr

Suchergebnisse

• 2020

  Lipid metabolism as target and modulator of KP1339 anticancer activity

  Baier, D. S., Schönhacker-Alte, B., Pirker, C., Englinger, B., Mohr, T., Meier-Menches, S., Roehrl, C., Moser, P., Laemmerer, A., Neuditschko, B., Niederstaetter, L., Brunmair, J., Schaier, M., Regner, B., Nowikovsky, K., Gerner, C., Koellensperger, G., Heffeter, P., Keppler, B. K. & Berger, W., Aug. 2020, in: Cancer Research. 80, 16, 2 S., Meeting Abstract: 1839 .

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2019

  Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

  Groza, D., Gehrig, S., Dinhof, C., Holcman, M., Pirker, C., Schueffl, H., Ogris, M., Lubitz, W., Keppler, B., Pashkunova-Martic, I., Kowol, C., Berger, W. & Heffeter, P., März 2019, in: European Journal of Cancer. 110, S1, S. S23-S24 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2018

  Update on NKP-1339/IT-139, a ruthenium-based GRP78 inhibitor in clinical development

  Schoenhacker-Alte, B., Baier, D., Mohr, T., Pirker, C., Buck, A., Hofmann, T., Keppler, B., Berger, W. & Heffeter, P., 2018, in: Oncology Research and Treatment. 41, Supplement 1, S. 47-48 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2017

  Association between improved liver function and selenium depends on C718T polymorphism in 3 '-untranslated region of glutathione peroxidase 4 and in humans

  Rohr-Udilova, N., Theiner, S., Beinhardt, S., Staettermayer, A., Scherzer, T., Seif, M., Koellensperger, G., Keppler, B., Eder, E., Willheim, C., Reiberger, T., Hofer, H., Peck-Radosavljevic, M., Ferenci, P. & Trauner, M., 2017, in: Journal of Hepatology. 66, S 1, S. S496-S497 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2015

  Investigation of factors involved in the hypersensitivity to KP1339-treatment

  Alte, B., Pirker, C., Mohr, T., Kryeziu, K., Keppler, B. K., Heffeter, P. & Berger, W., 1 Aug. 2015, in: Cancer Research. 75, 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Molecular mode of action of NKP-1339-a clinically investigated ruthenium-based drug - involves Nrf2 translocation and ER-associated protein degradation in colon carcinoma cell lines

  Flocke, L. S., Trondl, R., Bamonti, L., Jakupec, M. A. & Keppler, B. K., Sept. 2015, in: European Journal of Cancer. 51, S. S59-S59 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Multiscale distribution of anticancer platinum(IV) complexes in murine samples revealed by combination of NanoSIMS, LA-ICP-MS and TEM imaging

  Legin, A., Theiner, S., Schintlmeister, A., Reipert, S., Heffeter, P., Jakupec, M., Kowol, C., Galanski, M. S., Berger, W., Wagner, M. & Keppler, B., Sept. 2015, in: European Journal of Cancer. 51, S. S128-S128 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design

  Heffeter, P., Karnthaler-Benbakka, C., Groza, D., Kryeziu, K., Berger, W., Keppler, B. K. & Kowol, C. R., 1 Aug. 2015, in: Cancer Research. 75, 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Targeting DNA topoisomerase II alpha activity with thiomaltol-based organometallic complexes

  Novak, M., Hackl, C., Kandioller, W., Jakupec, M. & Keppler, B., Sept. 2015, in: European Journal of Cancer. 51, S. S73-S73 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2014

  A cobalt-based strategy for tumor targeting of EGFR-inhibitors

  Karnthaler-Benbakka, C., Groza, D., Kryeziu, K., Pichler, V., Roller, A., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S803-S803 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Asymmetric and symmetric Pt-IV complexes: new insights into the influence of the equatorial ligands sphere on reactivity and stability

  Pichler, V., Goeschl, S., Meier, S. M., Alexander, R., Jakupec, M. A., Galanski, M. S. & Keppler, B. K., März 2014, in: Journal of Biological Inorganic Chemistry. 19, S1, S. 598 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Asymmetric and symmetric PtIV complexes: new insights into the influence of the equatorial ligands sphere on reactivity and stability.

  Pichler, V., Göschl, S., Meier, S. M., Roller, A., Jakupec, M., Galanski, M. S. & Keppler, B., 2014, in: Journal of Biological Inorganic Chemistry. 19 Suppl., S. S598

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Behaviour of platinum(IV) complexes with prodrug function in different models of hypoxia

  Brynzak, E., Heffeter, P., Pichler, V., Jakupec, M. A. & Keppler, B. K., Nov. 2014, in: European Journal of Cancer. 50, S. 53-53 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Bioimaging and quantification of metal-based anticancer drugs using LA-ICP-MS

  Theiner, S., Egger, A., Heffeter, P., Kornauth, C., Theiner, S. & Keppler, B., März 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S681-S681 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Condensation properties of antitumor dinuclear Ru(II) arene complexes with aliphatic linkers: relation to DNA binding and cytotoxicity

  Novakova, O., Stankova, M., Malina, J., Keppler, B. K. & Brabec, V., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S816-S816 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Development of potential anticancer agents by coordination of bioactive molecules to organometallic fragments

  Kandioller, W., Mokesch, S., Hackl, C., Jakupec, M., Hartinger, C. G. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S749-S749 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Improved reaction conditions for the synthesis of novel KP1339 derivatives and preliminary investigations on their anticancer potential

  Kuhn, P-S., Pichler, V., Roller, A., Jakupec, M., Kandioller, W. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S801-S801 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Mixed monodentate tetracarboxylato platinum(IV) complexes featuring a symmetric or unsymmetric coordination sphere

  Hoefer, D., Varbanov, H. P., Galanski, M. S., Roller, A., Jakupec, M. A. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S784-S784 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Naphthoquinone derivatives as a bioactive ligand scaffold for the development of organometallic metallodrugs

  Hackl, C. M., Jakupec, M., Kandioller, W., Hartinger, C. G. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S872-S873 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Novel Metal(II)-Arene 2-Pyridinecarbothioamides: A Rationale to Orally Active Organometallic Anticancer Agents

  Meier, S. M., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M. A., Arion, V. A., Keppler, B. K., Hanif, M., Adhireksan, Z., Davey, C. A. & Hartinger, C. G., März 2014, in: Journal of Biological Inorganic Chemistry. 19, Supplement 1, S. S587-S587 Meeting Abstract 1702139.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Organometallic anticancer agents

  Moon, S., Wiezorek, S., Tong, K., Lin, C-H., Meier, S. M., Hanif, M., Jamieson, S., Jakupec, M. A., Adhireksan, Z., Davey, C. A., Keppler, B. K. & Hartinger, C. G., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S730-S730 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Platinum(IV) derivatives of oxaliplatin: Cellular effects and in vivo potency

  Goeschl, S., Pichler, V., Brynzak, E., Heffeter, P., Jungwirth, U., Jakupec, M. A., Berger, W., Galanski, M. S. & Keppler, B. K., Nov. 2014, in: European Journal of Cancer. 50, S. 22-22 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Recent advances in bioinorganic anticancer drug development

  Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S713-S713 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Surfactant-mediated activation of the lead anticancer ruthenium compound KP1019 by encapsulation into polymeric nanoparticles

  Fischer, B., Heffeter, P., Kryeziu, K., Gille, L., Meier, S. M., Berger, W., Kowol, C. R. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S802-S802 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Synthesis, characterization and anticancer activity of (thio)pyrone-derived organometallic complexes

  Schmidlehner, M., Pichler, V., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S802-S803 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Synthesis and characterization of bis-maleimide-functionalized platinum(IV) complexes for tumor-targeted drug delivery

  Mayr, J., Pichler, V., Heffeter, P., Doemoetoer, O., Enyedy, E. A., Hermann, G., Groza, D., Koellensperger, G., Galanski, M. S., Berger, W., Keppler, B. K. & Kowol, C. R., Aug. 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S782-S782 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Synthesis of Novel Di- and Trichelate Am(m)inebis(dicarboxylato)platinum(IV) Complexes and Their Physicochemical and Cytotoxic Evaluation

  Varbanov, H. P., Roller, A., Jakupec, M. A., Keppler, B. K. & Galanski, M. S., März 2014, in: Journal of Biological Inorganic Chemistry. 19, S. S590-S590 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2012

  Biological Effects of Ruthenium and Osmium Nitrosyl Complexes with Azole Heterocycles

  Novak, M., Büchel, G., Gavriluta, A., Tommasino, J. B., Luneau, D., Jakupec, M., Arion, V. & Keppler, B., 2012, in: European Journal of Cancer. Supplement. 48, Suppl.6, S. 161-161 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• ER Stress is an Additional Molecular Target for Triapine and Its Dimethylated Derivative

  Trondl, R., Heffeter, P., Kowol, C., Jakupec, M., Berger, W. & Keppler, B., 2012, in: European Journal of Cancer. Supplement. 48, Suppl.6, S. 168-168 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Methylation of the Oxaliplatin Cyclohexane Ring Leads to Reduced Side-effects and Enhanced Anticancer Activity

  Jungwirth, U., Xanthos, D. N., Gojo, J., Heffeter, P., Körner, W., Abramkin, S., Galanski, M. S., Keppler, B. & Berger, W., 2012, in: European Journal of Cancer. Supplement. 48, Suppl.5, S. 237-237 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Rapid Disturbance of the Intracellular Redox Balance Predicts Sensitivity to the Preclinical Anticancer Ruthenium Compound KP1339

  Kryeziu, K., Heffeter, P., Pirker, C., Senkiv, Y., Jungwirth, U., Keppler, B. & Berger, W., 2012, in: European Journal of Cancer. Supplement. 48, Suppl.5, S. 232-232 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2010

  Comparison of "conventional" radiosynthesis and microfluidic preparation of [18F]FE@SUPPY

  Ungersböck, J., Mien, L., Mitterhauser, M., Holley, A., Zeier, M., Dudczak, R., Kletter, K., Keppler, B. & Wadsak, W., Okt. 2010, in: European Journal of Nuclear Medicine and Molecular Imaging. 37, S. S316-S316 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• First Preparation of [18F]FE@PBM, a potential NET-PET-ligand

  Wadsak, W., Ungersboeck, J., Lanzenberger, R. R., Hoepping, A., Keppler, B. K., Kletter, K., Dudczak, R. & Mitterhauser, M., Okt. 2010, in: European Journal of Nuclear Medicine and Molecular Imaging. 37, S. S358-S359 2 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Further studies of bis(carboxylato)platinum(IV) compounds: Correlation between, liphoilicity, reduction potential, cellular accumulation and cytotoxicity

  Reithofer, M. R., Bytzek, A., Valiahdi, S. M., Kowol, C. R., Groessl, M., Galanski, M. S., Hartinger, C. G., Jakupec, M. A. & Keppler, B. K., 22 Aug. 2010, in: American Chemical Society. Abstracts of Papers (at the National Meeting). 240, 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Induction of endoplasmic reticulum stress by the novel anti-cancer compound KP46 and synergism with proteasome inhibition

  Gojo, J., Jungwirth, U., Heffeter, P., Atil, B., Micksche, M. & Keppler, B., 2010, in: European Journal of Cancer. Supplement. 8, 7, S. 53-53 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Stereoisomerism significantly impacts on the anticancer activity of novel oxaliplatin analogues in vitro and in vivo

  Jungwirth, U., Heffeter, P., Gojo, J., Abramkin, S., Meelich, K., Körner, W., Micksche, M., Galanski, M. S., Keppler, B. & Berger, W., 2010, in: European Journal of Cancer. Supplement. 8, 7, S. 141-141 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed

• Synergistic activity of the novel apoptosis-inducing compound KP1339 with the tyrosine kinase inhibitor sorafenib in cancer cell lines of diverse origin

  Heffeter, P., Atil, B., Jungwirth, U., Gal, E., Micksche, M., Keppler, B. & Berger, W., 2010, in: European Journal of Cancer. Supplement. 8, 7, S. 63-63 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2009

  Design of ruthenium-based small molecules as potential therapeutic agents

  Dyson, P. J., Nazarov, A. A., Hartinger, C. G. & Keppler, B. K., 16 Aug. 2009, in: American Chemical Society. Abstracts of Papers (at the National Meeting). 238, 1 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper › Peer Reviewed
• 2005

  Annual meeting of the working group for Pharmacology in Oncology and Hematology (APOH) of the Central European Society for Anticancer Drug Research (CESAR) during the symposium "Novel Approaches for the Discovery and the Development of Anticancer Agents"

  Keppler, B., 2005, in: International Journal of Clinical Pharmacology and Therapeutics. 43, 12, S. 566

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper
• 2003

  Amidines derived from Pt(IV)-mediated nitrile - Amino alcohol coupling and their Zn(II)-catalyzed conversion into oxazolines

  Makarycheva-Mikhailova, A. V., Kukushkin, V. Y., Nazarov, A., Garnovskii, D. A., Pombeiro, A. J. L., Haukka, M., Keppler, B. & Galanski, M. S., 2003, in: Inorganic Chemistry. 42, 8, S. 2805-2813 9 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper

  • Oxazoline 100%
  • Amino Alcohol 100%
  • Amidine 100%
  • Nitrile 100%
  • Ambient Reaction Temperature 16%
• 2002

  Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine 4N-dimethylthiosemicarbazone

  Arion, V., Jakupec, M., Galanski, M. S., Unfried, P. & Keppler, B., 2002, in: Journal of Inorganic Biochemistry. 91, 1, S. 298-305 8 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper

  • 71Ga NMR Spectrum 100%
  • 15N NMR Spectrum 100%
• 2000

  Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis

  Zenker, A., Galanski, M. S., Bereuter, T., Keppler, B. & Lindner, W., 2000, in: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 745, 1, S. 211-219 9 S.

  Veröffentlichungen: Beitrag in Fachzeitschrift › Meeting Abstract/Conference Paper

  • Cisplatin 100%
  • formation 100%
  • GMP 100%
  • Capillar Electrophoresis 100%
  • Capillary Electrophoresis 100%