A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)

Lenka Vargová; Kateřina Vymazalová; Ivana Jarošová; Ivo Mařík; Ladislava Horáčková; František Trampota; Katharina Rebay-Salisbury; Barbara Rendl; Fabian Kanz; Denisa Zlámalová

doi:10.1016/j.ijpp.2022.11.003

A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)

Lenka Vargová, Kateřina Vymazalová (Korresp. Autor*in), Ivana Jarošová, Ivo Mařík, Ladislava Horáčková, František Trampota, Katharina Rebay-Salisbury, Barbara Rendl, Fabian Kanz, Denisa Zlámalová

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts.

MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530.

METHODS: Morphological and metric analyses.

RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.

CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.

SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.

LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis.

SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.

Originalsprache	Englisch
Seiten (von - bis)	33-40
Seitenumfang	8
Fachzeitschrift	International Journal of Palaeopathology
Jahrgang	40
DOIs	https://doi.org/10.1016/j.ijpp.2022.11.003
Publikationsstatus	Veröffentlicht - März 2023
Extern publiziert	Ja

ÖFOS 2012

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10.1016/j.ijpp.2022.11.003

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Zitationsweisen

Vargová, L., Vymazalová, K., Jarošová, I., Mařík, I., Horáčková, L., Trampota, F., Rebay-Salisbury, K., Rendl, B., Kanz, F., & Zlámalová, D. (2023). A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic). International Journal of Palaeopathology, 40, 33-40. https://doi.org/10.1016/j.ijpp.2022.11.003

@article{81f7296135d6466982093ead3e467e7b,

title = "A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)",

abstract = "OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts.MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod s{\'y}pkou (Czech Republic), radio-carbon dated to AD 492-530.METHODS: Morphological and metric analyses.RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calv{\'e}-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis.SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.",

keywords = "Male, Humans, Adult, Middle Aged, Osteochondrodysplasias, Czech Republic, Cemeteries, Legg-Calve-Perthes Disease, Achondroplasia, Congenital defects, Disproporcional growth, Skeletal dysplasia, Tooth cementum annulation (TCA), Langobards",

author = "Lenka Vargov{\'a} and Kate{\v r}ina Vymazalov{\'a} and Ivana Jaro{\v s}ov{\'a} and Ivo Ma{\v r}{\'i}k and Ladislava Hor{\'a}{\v c}kov{\'a} and Franti{\v s}ek Trampota and Katharina Rebay-Salisbury and Barbara Rendl and Fabian Kanz and Denisa Zl{\'a}malov{\'a}",

year = "2023",

month = mar,

doi = "10.1016/j.ijpp.2022.11.003",

language = "English",

volume = "40",

pages = "33--40",

journal = "International Journal of Palaeopathology",

issn = "1879-9817",

}

Vargová, L, Vymazalová, K, Jarošová, I, Mařík, I, Horáčková, L, Trampota, F, Rebay-Salisbury, K, Rendl, B, Kanz, F & Zlámalová, D 2023, 'A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)', International Journal of Palaeopathology, Jg. 40, S. 33-40. https://doi.org/10.1016/j.ijpp.2022.11.003

TY - JOUR

T1 - A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)

AU - Vargová, Lenka

AU - Vymazalová, Kateřina

AU - Jarošová, Ivana

AU - Mařík, Ivo

AU - Horáčková, Ladislava

AU - Trampota, František

AU - Rebay-Salisbury, Katharina

AU - Rendl, Barbara

AU - Kanz, Fabian

AU - Zlámalová, Denisa

PY - 2023/3

Y1 - 2023/3

N2 - OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts.MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530.METHODS: Morphological and metric analyses.RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis.SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.

AB - OBJECTIVE: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts.MATERIALS: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492-530.METHODS: Morphological and metric analyses.RESULTS: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.CONCLUSIONS: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.SIGNIFICANCE: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.LIMITATIONS: The final diagnosis is limited by the lack of genetic analysis.SUGGESTION FOR THE FUTURE RESEARCH: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.

KW - Male

KW - Humans

KW - Adult

KW - Middle Aged

KW - Osteochondrodysplasias

KW - Czech Republic

KW - Cemeteries

KW - Legg-Calve-Perthes Disease

KW - Achondroplasia

KW - Congenital defects

KW - Disproporcional growth

KW - Skeletal dysplasia

KW - Tooth cementum annulation (TCA)

KW - Langobards

UR - http://www.scopus.com/inward/record.url?scp=85143149989&partnerID=8YFLogxK

U2 - 10.1016/j.ijpp.2022.11.003

DO - 10.1016/j.ijpp.2022.11.003

M3 - Article

C2 - 36455429

VL - 40

SP - 33

EP - 40

JO - International Journal of Palaeopathology

JF - International Journal of Palaeopathology

SN - 1879-9817

ER -