Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit

Hanne Jorgensen; Kristin F. Degnes; Havard Sletta; Espen Fjaervik; Alexander Dikiy; Lars Herfindal; Per Bruheim; Geir Klinkenberg; Harald Bredholt; Gyrid Nygard; Stein O. Doskeland; Trond E. Ellingsen; Sergey B. Zotchev

doi:10.1016/j.chembiol.2009.09.014

Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit

Hanne Jorgensen, Kristin F. Degnes, Havard Sletta, Espen Fjaervik, Alexander Dikiy, Lars Herfindal, Per Bruheim, Geir Klinkenberg, Harald Bredholt, Gyrid Nygard, Stein O. Doskeland, Trond E. Ellingsen, Sergey B. Zotchev

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Originalsprache	Englisch
Seiten (von - bis)	1109-1121
Seitenumfang	13
Fachzeitschrift	Chemistry & Biology
Jahrgang	16
Ausgabenummer	10
DOIs	https://doi.org/10.1016/j.chembiol.2009.09.014
Publikationsstatus	Veröffentlicht - 30 Okt. 2009

ÖFOS 2012

106022 Mikrobiologie
106013 Genetik
106002 Biochemie
104013 Naturstoffchemie

Zugriff auf Dokument

10.1016/j.chembiol.2009.09.014

Zitationsweisen

Jorgensen, H., Degnes, K. F., Sletta, H., Fjaervik, E., Dikiy, A., Herfindal, L., Bruheim, P., Klinkenberg, G., Bredholt, H., Nygard, G., Doskeland, S. O., Ellingsen, T. E., & Zotchev, S. B. (2009). Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit. Chemistry & Biology, 16(10), 1109-1121. https://doi.org/10.1016/j.chembiol.2009.09.014

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title = "Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit",

keywords = "NONRIBOSOMAL PEPTIDE SYNTHETASES, STREPTOMYCES-NOURSEI ATCC-11455, GENE-CLUSTER, POLYKETIDE SYNTHASE, MACROCYCLIC LACTAM, ANTITUMOR-ACTIVITY, CHEMICAL MODIFICATION, SUBSTRATE-SPECIFICITY, BIOLOGICAL-ACTIVITY, POLYENE MACROLIDES",

author = "Hanne Jorgensen and Degnes, {Kristin F.} and Havard Sletta and Espen Fjaervik and Alexander Dikiy and Lars Herfindal and Per Bruheim and Geir Klinkenberg and Harald Bredholt and Gyrid Nygard and Doskeland, {Stein O.} and Ellingsen, {Trond E.} and Zotchev, {Sergey B.}",

year = "2009",

month = oct,

day = "30",

doi = "10.1016/j.chembiol.2009.09.014",

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Jorgensen, H, Degnes, KF, Sletta, H, Fjaervik, E, Dikiy, A, Herfindal, L, Bruheim, P, Klinkenberg, G, Bredholt, H, Nygard, G, Doskeland, SO, Ellingsen, TE & Zotchev, SB 2009, 'Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit', Chemistry & Biology, Jg. 16, Nr. 10, S. 1109-1121. https://doi.org/10.1016/j.chembiol.2009.09.014

TY - JOUR

T1 - Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit

AU - Jorgensen, Hanne

AU - Degnes, Kristin F.

AU - Sletta, Havard

AU - Fjaervik, Espen

AU - Dikiy, Alexander

AU - Herfindal, Lars

AU - Bruheim, Per

AU - Klinkenberg, Geir

AU - Bredholt, Harald

AU - Nygard, Gyrid

AU - Doskeland, Stein O.

AU - Ellingsen, Trond E.

AU - Zotchev, Sergey B.

PY - 2009/10/30

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KW - NONRIBOSOMAL PEPTIDE SYNTHETASES

KW - STREPTOMYCES-NOURSEI ATCC-11455

KW - GENE-CLUSTER

KW - POLYKETIDE SYNTHASE

KW - MACROCYCLIC LACTAM

KW - ANTITUMOR-ACTIVITY

KW - CHEMICAL MODIFICATION

KW - SUBSTRATE-SPECIFICITY

KW - BIOLOGICAL-ACTIVITY

KW - POLYENE MACROLIDES

U2 - 10.1016/j.chembiol.2009.09.014

DO - 10.1016/j.chembiol.2009.09.014

M3 - Article

SN - 1074-5521

VL - 16

SP - 1109

EP - 1121

JO - Chemistry & Biology

JF - Chemistry & Biology

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