Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing

Verena Jantsch, Lois Tang, Pawel Pasierbek, Alexandra Penkner, S. Nayak, Antoine Baudrimont, Tim Schedl, Anton Gartner, Josef Loidl

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

A novel gene, prom-1, was isolated in a screen for Caenorhabditis elegans mutants with increased apoptosis in the germline. prom-1 encodes an F-box protein with limited homology to the putative human tumor suppressor FBXO47. Mutations in the prom-1 locus cause a strong reduction in bivalent formation, which results in increased embryonic lethality and a Him phenotype. Furthermore, retarded and asynchronous nuclear reorganization as well as reduced homologous synapsis occur during meiotic prophase. Accumulation of recombination protein RAD-51 in meiotic nuclei suggests disturbed repair of double-stranded DNA breaks. Nuclei in prom-1 mutant gonads timely complete mitotic proliferation and premeiotic replication, but they undergo prolonged delay upon meiotic entry. We, therefore, propose that prom-1 regulates the timely progression through meiotic prophase I and that in its absence the recognition of homologous chromosomes is strongly impaired.
OriginalspracheEnglisch
Seiten (von - bis)4691-5153
FachzeitschriftMolecular Biology of the Cell
Jahrgang18
Ausgabenummer12
DOIs
PublikationsstatusVeröffentlicht - 1 Dez. 2007

ÖFOS 2012

  • 106052 Zellbiologie

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