Cell growth on prestructured microelectronic semiconductor materials

Heinz D Wanzenboeck, Christian Almeder, Christoph Pacher, Emmerich Bertagnolli, Elisabeth Bogner, Michael Wirth, Franz Gabor

Veröffentlichungen: Beitrag in BuchBeitrag in Konferenzband

Abstract

Cell-based biosensors allow to couple the exquisite selectivity of living systems with the processing power of modern microelectronics. Bioelectronic transducers offer powerful new analytical tools with major applications in medicine, pharmaceutical research, environmental diagnostics and the food and processing industries. The interface between inorganic materials and living cells is crucial for the operation of biosensors. A systematic study of the survivability and the growth of an exemplary cell culture on various materials used in microelectronics was performed. The viability and the adhesion of colon carcinoma cells (Caco-2) was tested on an assortment of commonly used metals, dielectrics and semiconductor materials. Growth inhibiting materials such as copper and blank gallium arsenide have been idientified as well as highly biocompatible materials such as silicon, silicon nitride, chromium and gold. Also the growth on the metal-dielectric boundary were performed and neither the sub200 nm height step nor the change of the material showed to effect t he cell growth. Several materials have been successfully tested to facilitate the growth of cell structures. The results allow a versatile application for microelectrode arrays. © 2004 Materials Research Society.
OriginalspracheEnglisch
TitelArchitecture and application of biomaterials and biomolecular materials
Untertitel2003 MRS Fall Meeting; Boston, MA; United States; 1 December 2003 through 4 December 2003
Redakteure*innenJoyce Y. Wong
ErscheinungsortWarrendale
Herausgeber (Verlag)Materials Research Society
Seiten369-375
Seitenumfang7
ISBN (Print)1-55899-745-8
PublikationsstatusVeröffentlicht - 2004

Publikationsreihe

ReiheMaterials Research Society Symposium Proceedings
Nummer1
BandEXS-1
ISSN0272-9172

ÖFOS 2012

  • 3012 Pharmazie, Pharmakologie, Toxikologie

Zitationsweisen