Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells

Philipp Saiko, Zsuzsanna Horvath, Christoph Illmer, Wolfgang Bauer, Thomas Hoechtl, Natascha Erlach, Michael Grusch, Georg Krupitza, Robert Mader, Walter Jäger, Herbert Schott, Ram P. Agarwal, Thomas Szekeres (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (# 2 and # 10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer # 2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted. Œ 2005 Elsevier Ltd. All rights reserved.
OriginalspracheEnglisch
Seiten (von - bis)785-791
Seitenumfang7
FachzeitschriftLeukemia Research
Jahrgang29
Ausgabenummer7
PublikationsstatusVeröffentlicht - 2005

ÖFOS 2012

  • 3012 Pharmazie, Pharmakologie, Toxikologie

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