Drug discovery FAQs: Workflows for answering multidomain drug discovery questions

Christine Chichester; Daniela Digles; Ronald Siebes; Antonis Loizou; Paul Groth; Lee Harland

doi:10.1016/j.drudis.2014.11.006

Drug discovery FAQs: Workflows for answering multidomain drug discovery questions

Christine Chichester, Daniela Digles, Ronald Siebes, Antonis Loizou, Paul Groth, Lee Harland

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

Modern data-driven drug discovery requires integrated resources to support decision-making and enable new discoveries. The Open PHACTS Discovery Platform (http://dev.openphacts.org) was built to address this requirement by focusing on drug discovery questions that are of high priority to the pharmaceutical industry. Although complex, most of these frequently asked questions (FAQs) revolve around the combination of data concerning compounds, targets, pathways and diseases. Computational drug discovery using workflow tools and the integrated resources of Open PHACTS can deliver answers to most of these questions. Here, we report on a selection of workflows used for solving these use cases and discuss some of the research challenges. The workflows are accessible online from myExperiment (http://www.myexperiment.org) and are available for reuse by the scientific community.

Originalsprache	Englisch
Seiten (von - bis)	399-405
Seitenumfang	7
Fachzeitschrift	Drug Discovery Today
Jahrgang	20
Ausgabenummer	4
DOIs	https://doi.org/10.1016/j.drudis.2014.11.006
Publikationsstatus	Veröffentlicht - 1 Apr. 2015

ÖFOS 2012

301207 Pharmazeutische Chemie

Zugriff auf Dokument

10.1016/j.drudis.2014.11.006

Andere Dateien und Links

http://www.scopus.com/inward/record.url?scp=84928744699&partnerID=8YFLogxK

Zitationsweisen

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