Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents

D. Kreutz, C. Gerner, S. M. Meier-Menches (Korresp. Autor*in)

Veröffentlichungen: Beitrag in BuchBeitrag in Buch/SammelbandPeer Reviewed

Abstract

Next-generation metal-based pharmaceuticals are considered promising therapeutic agents, which may follow novel modes of action and engage with different targets compared to classical platinum(ii) anticancer agents. However, appropriate methods and assays are required to provide evidence of such unprecedented drug effects. Mass spectrometry (MS) has proved useful in probing the reactivity and selectivity of metal-based anticancer agents on a molecular level and recently also in the cellular context, especially with regard to the proteome. This chapter will discuss the design and use of competitive experiments to investigate activation pathways and binding preferences of metal-based anticancer agents by identifying reaction products via different MS setups. Moreover, cell-based approaches are described to obtain insights into novel potential targets and modes of action. Thus, mass spectrometry emerges as an enabling technology that connects molecules to mechanisms, highlighting the broad applicability of this analytical technique to the discovery and understanding of metal-based anticancer agents.
OriginalspracheEnglisch
TitelMetal-based Anticancer Agents
Redakteure*innenAngela Casini, Anne Vessieres, Samuel M. Meier-Menches
Herausgeber (Verlag)Royal Society of Chemistry
KapitelCHAPTER 10
Seiten246-270
Seitenumfang25
ISBN (elektronisch) 978-1-78801-767-1
ISBN (Print)978-1-78801-406-9
DOIs
PublikationsstatusVeröffentlicht - 23 Apr. 2019

Publikationsreihe

ReiheRSC Metallobiology
Nummer14
Band2019-January
ISSN2045-547X

ÖFOS 2012

  • 104002 Analytische Chemie
  • 104003 Anorganische Chemie
  • 301904 Krebsforschung

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