Enantiomer and Topoisomer Separation of Acidic Compounds on Anion-Exchanger Chiral Stationary Phases by HPLC and SFC

Pilar Franco, Tong Zhang, Andrea Gargano, Marek Mahut, Michael Lämmerhofer, Wolfgang Lindner (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

Quinine- and quinidine-derived anion-exchanger chiral stationary phases are versatile tools for enantiomer separation of acidic compounds in high performance liquid chromatography (HPLC). This article demonstrates their recognition ability in specific HPLC applications, involving enantiomer resolution and plasmid topoisomer separation. The extension of their applications from HPLC to supercritical fluid chromatography (SFC) was also investigated, with the aim of assessing the influence of a series of parameters and gaining insight into the general approaches for SFC method development and optimization.
OriginalspracheEnglisch
Seiten (von - bis)600-610
Seitenumfang11
FachzeitschriftL C G C Europe / LC - GC Europe
Jahrgang25
Ausgabenummer11
PublikationsstatusVeröffentlicht - 2012

ÖFOS 2012

  • 104002 Analytische Chemie

Zitationsweisen