Evolutionarily conserved human targets of adenosine to inosine RNA editing

Erez Y. Levanon, Eva-Martina Hallegger, Yaron Kinar, Ronen Shemesh, Kristina Djinovic-Carugo, Gideon Rechavi, Franz-Michael Jantsch, Eli Eisenberg, Ursula Thalhammer

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

A-to-I RNA editing by ADARs is a post-transcriptional mechanism for expanding the proteomic repertoire. Genetic recoding by editing was so far observed for only a few mammalian RNAs that are predominantly expressed in nervous tissues. However, as these editing targets fail to explain the broad and severe phenotypes of ADAR1 knockout mice, additional targets for editing by ADARs were always expected. Using comparative genomics and expressed sequence analysis, we identified and experimentally verified four additional candidate human substrates for ADAR-mediated editing: FLNA, BLCAP, CYFIP2 and IGFBP7. Additionally, editing of three of these substrates was verified in the mouse while two of them were validated in chicken. Interestingly, none of these substrates encodes a receptor protein but two of them are strongly expressed in the CNS and seem important for proper nervous system function. The editing pattern observed suggests that some of the affected proteins might have altered physiological properties leaving the possibility that they can be related to the phenotypes of ADAR1 knockout mice. Œ The Author 2005. Published by Oxford University Press. All rights reserved.
OriginalspracheEnglisch
Seiten (von - bis)1162-1168
Seitenumfang7
FachzeitschriftNucleic Acids Research
Jahrgang33
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - 2005

ÖFOS 2012

  • 106041 Strukturbiologie
  • 1060 Biologie

Fingerprint

Untersuchen Sie die Forschungsthemen von „Evolutionarily conserved human targets of adenosine to inosine RNA editing“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitationsweisen