Abstract
To gain more insight into the factors controlling efficient cysteine arylation by cyclometallated Au(III)complexes, the reaction between selected gold compounds and different peptides was investigated by high-resolution liquid chromatography electrospray ionization mass spectrometry (HR-LC-ESI-MS). The deduced mechanisms of C-S cross-coupling, also supported by density functional theory (DFT) and quantum mechanics/molecular mechanics (QM/MM) calculations, evidenced the key role of secondary peptidic gold binding sites in favouring the process of reductive elimination.
Originalsprache | Englisch |
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Seiten (von - bis) | 3071-3076 |
Seitenumfang | 6 |
Fachzeitschrift | ChemBioChem: a european journal of chemical biology |
Jahrgang | 21 |
Ausgabenummer | 21 |
DOIs | |
Publikationsstatus | Veröffentlicht - 8 Juli 2020 |
ÖFOS 2012
- 106002 Biochemie
- 106023 Molekularbiologie
- 301305 Medizinische Chemie