Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat

Ringo Grombe; Günter M Allmaier; Jean Charoud-Got; Agnieszka  Dudkiewicz; Håkan Emteborg; Thilo Hofmann; Erik H. Larsen; Angela Lehner; Meritxell Llinas; Katrin Loeschner; Kristian Molhave; Ruud Peters; John Seghers; Conxita Solans; Frank von der Kammer; Stephan Wagner; Stefan Weigel; Thomas P J Linsinger

doi:10.1007/s00769-014-1100-5

Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat

Ringo Grombe
, Günter M Allmaier
, Jean Charoud-Got
, Agnieszka Dudkiewicz
, Håkan Emteborg
, Thilo Hofmann
, Erik H. Larsen
, Angela Lehner
, Meritxell Llinas
, Katrin Loeschner
, Kristian Molhave
, Ruud Peters
, John Seghers
, Conxita Solans
, Frank von der Kammer
, Stephan Wagner
, Stefan Weigel
, Thomas P J Linsinger (Korresp. Autor*in)

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4 °C, 18 °C and 60 °C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60 °C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain.
Accreditation and Quality Assurance Accreditation and Quality Assurance Look
Inside
Other actions

Export citation
Register for Journal Updates
About This Journal
Reprints and Permissions
Add to Papers

Share
Share this content on Facebook Share this content on Twitter Share this content on LinkedIn

Originalsprache	Englisch
Seiten (von - bis)	3-16
Seitenumfang	14
Fachzeitschrift	Accrediation and Quality Assurance
Jahrgang	20
Ausgabenummer	1
Frühes Online-Datum	14 Jan. 2015
DOIs	https://doi.org/10.1007/s00769-014-1100-5
Publikationsstatus	Veröffentlicht - 1 Feb. 2015

Fördermittel

The work leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007\u20132013) under grant agreement no 245162. The authors thank Mrs. Meeus (EC JRC-IRMM) for conducting the microbiology tests.

ÖFOS 2012

104023 Umweltchemie
104002 Analytische Chemie
105904 Umweltforschung
210006 Nanotechnologie

Schlagwörter

Engineered nanoparticles
Food
Reference material
Matrix reference materials
Silver nanoparticles

Zugriff auf Dokument

10.1007/s00769-014-1100-5

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

Zitationsweisen

Grombe, R., Allmaier, G. M., Charoud-Got, J., Dudkiewicz, A., Emteborg, H., Hofmann, T., Larsen, E. H., Lehner, A., Llinas, M., Loeschner, K., Molhave, K., Peters, R., Seghers, J., Solans, C., von der Kammer, F., Wagner, S., Weigel, S., & Linsinger, T. P. J. (2015). Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat. Accrediation and Quality Assurance, 20(1), 3-16. https://doi.org/10.1007/s00769-014-1100-5

@article{fc6cefd7da134d2e8aab713f6365b6ab,

title = "Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat",

abstract = " The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4 °C, 18 °C and 60 °C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60 °C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain. Accreditation and Quality Assurance Accreditation and Quality Assurance Look Inside Other actions Export citation Register for Journal Updates About This Journal Reprints and Permissions Add to Papers Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn ",

keywords = "Engineered nanoparticles, Food, Reference material, Matrix reference materials, Silver nanoparticles, Engineered nanoparticles, Food, Matrix reference materials, Reference material, Silver nanoparticles",

author = "Ringo Grombe and Allmaier, \{G{\"u}nter M\} and Jean Charoud-Got and Agnieszka Dudkiewicz and H{\aa}kan Emteborg and Thilo Hofmann and Larsen, \{Erik H.\} and Angela Lehner and Meritxell Llinas and Katrin Loeschner and Kristian Molhave and Ruud Peters and John Seghers and Conxita Solans and \{von der Kammer\}, Frank and Stephan Wagner and Stefan Weigel and Linsinger, \{Thomas P J\}",

note = "Publisher Copyright: {\textcopyright} 2015, European Union.",

year = "2015",

month = feb,

day = "1",

doi = "10.1007/s00769-014-1100-5",

language = "English",

volume = "20",

pages = "3--16",

journal = "Accrediation and Quality Assurance",

issn = "0949-1775",

number = "1",

}

Grombe, R, Allmaier, GM, Charoud-Got, J, Dudkiewicz, A, Emteborg, H, Hofmann, T, Larsen, EH, Lehner, A, Llinas, M, Loeschner, K, Molhave, K, Peters, R, Seghers, J, Solans, C, von der Kammer, F, Wagner, S, Weigel, S & Linsinger, TPJ 2015, 'Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat', Accrediation and Quality Assurance, Jg. 20, Nr. 1, S. 3-16. https://doi.org/10.1007/s00769-014-1100-5

TY - JOUR

T1 - Feasibility of the development of reference materials for the detection of Ag nanoparticles in food: neat dispersions and spiked chicken meat

AU - Grombe, Ringo

AU - Allmaier, Günter M

AU - Charoud-Got, Jean

AU - Dudkiewicz, Agnieszka

AU - Emteborg, Håkan

AU - Hofmann, Thilo

AU - Larsen, Erik H.

AU - Lehner, Angela

AU - Llinas, Meritxell

AU - Loeschner, Katrin

AU - Molhave, Kristian

AU - Peters, Ruud

AU - Seghers, John

AU - Solans, Conxita

AU - von der Kammer, Frank

AU - Wagner, Stephan

AU - Weigel, Stefan

AU - Linsinger, Thomas P J

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4 °C, 18 °C and 60 °C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60 °C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain. Accreditation and Quality Assurance Accreditation and Quality Assurance Look Inside Other actions Export citation Register for Journal Updates About This Journal Reprints and Permissions Add to Papers Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn

AB - The feasibility of producing colloidal silver nanoparticle reference materials and silver nanoparticle spiked reference matrix materials was investigated. Two concentrations of PVP-coated silver nanoparticle dispersions were evaluated and used to spike chicken meat, with the aim of producing a set of reference materials to support the development of analytical methods for the detection and quantification of nanoparticles in food. Aqueous silver nanoparticle (AgNP) dispersions were evaluated for their homogeneity of mass fraction and particle size and found sufficiently homogeneous to be used as reference materials. Stability studies at 4 °C, 18 °C and 60 °C demonstrated sufficient short- and long-term stability, although particle size decreases in a linear fashion at 60 °C. The AgNP dispersions were characterized for total Ag mass fraction by ICP-OES, dissolved Ag content by ultrafiltration-ICP-MS, as well as AgNP particle size by dynamic light scattering, transmission electron microscopy (TEM) and gas-phase electrophoretic molecular mobility analysis. Chicken breasts were homogenized by cryo-milling and spiked with aqueous AgNP dispersions. Rapid freezing over liquid nitrogen resulted in homogeneous and stable materials. The spiked chicken materials were characterized for their total Ag mass fraction by neutron activation analysis and for the AgNP particle size by TEM and single-particle inductively coupled plasma mass spectrometry. The observed differences in particle sizes between the spiked chicken samples and the original silver dispersions indicate relevant matrix effects. The materials demonstrate that production and characterization of reference materials for the detection and quantification of silver nanoparticles in meat are feasible, but challenges especially in assessing stability and having sufficiently precise methods for assessment of homogeneity and stability remain. Accreditation and Quality Assurance Accreditation and Quality Assurance Look Inside Other actions Export citation Register for Journal Updates About This Journal Reprints and Permissions Add to Papers Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn

KW - Engineered nanoparticles

KW - Food

KW - Reference material

KW - Matrix reference materials

KW - Silver nanoparticles

KW - Engineered nanoparticles

KW - Food

KW - Matrix reference materials

KW - Reference material

KW - Silver nanoparticles

UR - https://www.scopus.com/pages/publications/84939121655

U2 - 10.1007/s00769-014-1100-5

DO - 10.1007/s00769-014-1100-5

M3 - Article

SN - 0949-1775

VL - 20

SP - 3

EP - 16

JO - Accrediation and Quality Assurance

JF - Accrediation and Quality Assurance

IS - 1

ER -