TY - JOUR
T1 - Heterodinucleoside phosphates of 5-Fluorodeoxyuridine and Arabinofuranosylcytosine - New drugs in cancer chemotherapy?
AU - Saiko, Philipp
AU - Horvath, Zsuzsanna
AU - Jaeger, Walter
AU - Schott, Herbert
AU - Fritzer-Szekeres, Monika
AU - Szekeres, Thomas
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The incidence of cancer is rapidly increasing and malignancies have become the number two cause of deaths in the Western world after cardiovascular diseases. In particular, colon cancer represents one of the most frequent types of malignancy. Chemotherapy is, in addition to surgery and irradiation, still one of the main treatment options against this group of diseases. Here, several chemotherapeutic treatment modalities and anticancer compounds for the treatment of colon cancer are reviewed. In particular, a newer group of heterodinucleoside phosphates (dimers), consisting of two well known antimetabolites (5-FdUrd (5-Fluorodeoxyuridine) and Ara-C (Cytarabine)), are presented. These dimers were evaluated in several studies and might offer an additional option for the treatment of various malignancies, in particular colon carcinomas. The results are summarized in detail, as these dimers might have some significant advantages when compared with conventional regimens; they might be administered orally and might constitute an alternative treatment option for resistant tumors.
AB - The incidence of cancer is rapidly increasing and malignancies have become the number two cause of deaths in the Western world after cardiovascular diseases. In particular, colon cancer represents one of the most frequent types of malignancy. Chemotherapy is, in addition to surgery and irradiation, still one of the main treatment options against this group of diseases. Here, several chemotherapeutic treatment modalities and anticancer compounds for the treatment of colon cancer are reviewed. In particular, a newer group of heterodinucleoside phosphates (dimers), consisting of two well known antimetabolites (5-FdUrd (5-Fluorodeoxyuridine) and Ara-C (Cytarabine)), are presented. These dimers were evaluated in several studies and might offer an additional option for the treatment of various malignancies, in particular colon carcinomas. The results are summarized in detail, as these dimers might have some significant advantages when compared with conventional regimens; they might be administered orally and might constitute an alternative treatment option for resistant tumors.
KW - 5-Fluorodeoxyuridine
KW - Arabinofuranosylcytosine
KW - Heterodinucleoside phosphates
UR - http://www.scopus.com/inward/record.url?scp=16244375237&partnerID=8YFLogxK
M3 - Article
C2 - 15796176
AN - SCOPUS:16244375237
SN - 0258-851X
VL - 19
SP - 205
EP - 214
JO - IN VIVO
JF - IN VIVO
IS - 1
ER -