TY - CHAP
T1 - Imprinted Polymers on the Route to Plastibodies for Biomacromolecules (MIPs), Viruses (VIPs), and Cells (CIPs)
AU - Zhang, Xiaorong
AU - Yarman, Aysu
AU - Bagheri, Mahdieh
AU - El-Sherbiny, Ibrahim M.
AU - Hassan, Rabeay Y.A.
AU - Waffo, Armel Franklin Tadjoung
AU - Kurbanoglu, Sevinc
AU - Zebger, Ingo
AU - Karabulut, Tutku Ceren
AU - Bier, Frank F.
AU - Lieberzeit, Peter
AU - Scheller, Frieder W.
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.
PY - 2024
Y1 - 2024
N2 - Around 30% of the scientific papers published on imprinted polymers describe the recognition of proteins, nucleic acids, viruses, and cells. The straightforward synthesis from only one up to six functional monomers and the simple integration into a sensor are significant advantages as compared with enzymes or antibodies. Furthermore, they can be synthesized against toxic substances and structures of low immunogenicity and allow multi-analyte measurements via multi-template synthesis. The affinity is sufficiently high for protein biomarkers, DNA, viruses, and cells. However, the cross-reactivity of highly abundant proteins is still a challenge.
AB - Around 30% of the scientific papers published on imprinted polymers describe the recognition of proteins, nucleic acids, viruses, and cells. The straightforward synthesis from only one up to six functional monomers and the simple integration into a sensor are significant advantages as compared with enzymes or antibodies. Furthermore, they can be synthesized against toxic substances and structures of low immunogenicity and allow multi-analyte measurements via multi-template synthesis. The affinity is sufficiently high for protein biomarkers, DNA, viruses, and cells. However, the cross-reactivity of highly abundant proteins is still a challenge.
KW - Biomimetic sensors
KW - Cell-Imprinted Polymers (CIPs)
KW - MIPs for proteins and nucleic acids
KW - Plastibodies
KW - Virus-Imprinted Polymers (VIPs)
UR - http://www.scopus.com/inward/record.url?scp=85177697433&partnerID=8YFLogxK
U2 - 10.1007/10_2023_234
DO - 10.1007/10_2023_234
M3 - Chapter
C2 - 37884758
AN - SCOPUS:85177697433
VL - 187
T3 - Advances in Biochemical Engineering/Biotechnology
SP - 107
EP - 148
BT - TRENDS IN BIOSENSING RESEARCH
PB - Springer
ER -