Abstract
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by an aberrant metabolic phenotype with high metastatic capacity, resulting in poor patient prognoses and low survival rates. We designed a series of novel Au-III cyclometalated prodrugs of energy-disrupting Type II antidiabetic drugs namely, metformin and phenformin. Prodrug activation and release of the metformin ligand was achieved by tuning the cyclometalated Au-III fragment. The lead complex 3met was 6000-fold more cytotoxic compared to uncoordinated metformin and significantly reduced tumor burden in mice with aggressive breast cancers with lymphocytic infiltration into tumor tissues. These effects was ascribed to 3met interfering with energy production in TNBCs and inhibiting associated pro-survival responses to induce deadly metabolic catastrophe.
Originalsprache | Englisch |
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Seiten (von - bis) | 13405-13413 |
Seitenumfang | 9 |
Fachzeitschrift | Angewandte Chemie (International Edition) |
Jahrgang | 60 |
Ausgabenummer | 24 |
DOIs | |
Publikationsstatus | Veröffentlicht - 7 Juni 2021 |
ÖFOS 2012
- 301904 Krebsforschung
- 301207 Pharmazeutische Chemie