Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Jayne Louise Wilson; Thomas Naegele; Monika Linke; Florian Demel; Stephanie D. Fritsch; Hannah Katharina Mayr; Zhengnan Cai; Karl Katholnig; Xiaoliang Sun; Lena Fragner; Anne Miller; Arvand Haschemi; Alexandra Popa; Andreas Bergthaler; Markus Hengstschlaeger; Thomas Weichhart; Wolfram Weckwerth

doi:10.1016/j.celrep.2020.01.011

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Jayne Louise Wilson, Thomas Naegele, Monika Linke, Florian Demel, Stephanie D. Fritsch, Hannah Katharina Mayr, Zhengnan Cai, Karl Katholnig, Xiaoliang Sun, Lena Fragner, Anne Miller, Arvand Haschemi, Alexandra Popa, Andreas Bergthaler, Markus Hengstschlaeger, Thomas Weichhart (Korresp. Autor*in), Wolfram Weckwerth (Korresp. Autor*in)

Department für Funktionelle und Evolutionäre Ökologie

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Originalsprache	Englisch
Aufsatznummer	e7
Seiten (von - bis)	1542-1552
Fachzeitschrift	Cell Reports
Jahrgang	30
Ausgabenummer	5
DOIs	https://doi.org/10.1016/j.celrep.2020.01.011
Publikationsstatus	Veröffentlicht - 4 Feb. 2020

ÖFOS 2012

106002 Biochemie
101028 Mathematische Modellierung
106052 Zellbiologie
106044 Systembiologie

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10.1016/j.celrep.2020.01.011Lizenz: CC BY-NC-ND 4.0

https://phaidra.univie.ac.at/o:1241343Lizenz: CC BY-NC-ND 4.0

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Verknüpfung zur Publikation in Scopus

Zitationsweisen

Wilson, J. L., Naegele, T., Linke, M., Demel, F., Fritsch, S. D., Mayr, H. K., Cai, Z., Katholnig, K., Sun, X., Fragner, L., Miller, A., Haschemi, A., Popa, A., Bergthaler, A., Hengstschlaeger, M., Weichhart, T., & Weckwerth, W. (2020). Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation. Cell Reports, 30(5), 1542-1552. Artikel e7. https://doi.org/10.1016/j.celrep.2020.01.011

@article{8453632db7f043fe8994c44a676803b5,

title = "Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation",

keywords = "SERINE SYNTHESIS, IDENTIFICATION, DEHYDROGENASE, GLYCINE, BIOSYNTHESIS, ACTIVATION, INHIBITOR, CYTOSCAPE, NETWORKS, PATHWAY, biochemical Jacobian, macrophage proliferation, serine/glycine pathway, metabolic modeling, macrophage polarization, Tsc2, Phgdh, tumor-associated macrophages, metabolomics, mTOR, cancer",

author = "Wilson, {Jayne Louise} and Thomas Naegele and Monika Linke and Florian Demel and Fritsch, {Stephanie D.} and Mayr, {Hannah Katharina} and Zhengnan Cai and Karl Katholnig and Xiaoliang Sun and Lena Fragner and Anne Miller and Arvand Haschemi and Alexandra Popa and Andreas Bergthaler and Markus Hengstschlaeger and Thomas Weichhart and Wolfram Weckwerth",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = feb,

day = "4",

doi = "10.1016/j.celrep.2020.01.011",

language = "English",

volume = "30",

pages = "1542--1552",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "CELL PRESS",

number = "5",

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Wilson, JL, Naegele, T, Linke, M, Demel, F, Fritsch, SD, Mayr, HK, Cai, Z, Katholnig, K, Sun, X, Fragner, L, Miller, A, Haschemi, A, Popa, A, Bergthaler, A, Hengstschlaeger, M, Weichhart, T & Weckwerth, W 2020, 'Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation', Cell Reports, Jg. 30, Nr. 5, e7, S. 1542-1552. https://doi.org/10.1016/j.celrep.2020.01.011

TY - JOUR

T1 - Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

AU - Wilson, Jayne Louise

AU - Naegele, Thomas

AU - Linke, Monika

AU - Demel, Florian

AU - Fritsch, Stephanie D.

AU - Mayr, Hannah Katharina

AU - Cai, Zhengnan

AU - Katholnig, Karl

AU - Sun, Xiaoliang

AU - Fragner, Lena

AU - Miller, Anne

AU - Haschemi, Arvand

AU - Popa, Alexandra

AU - Bergthaler, Andreas

AU - Hengstschlaeger, Markus

AU - Weichhart, Thomas

AU - Weckwerth, Wolfram

PY - 2020/2/4

Y1 - 2020/2/4

KW - SERINE SYNTHESIS

KW - IDENTIFICATION

KW - DEHYDROGENASE

KW - GLYCINE

KW - BIOSYNTHESIS

KW - ACTIVATION

KW - INHIBITOR

KW - CYTOSCAPE

KW - NETWORKS

KW - PATHWAY

KW - biochemical Jacobian

KW - macrophage proliferation

KW - serine/glycine pathway

KW - metabolic modeling

KW - macrophage polarization

KW - Tsc2

KW - Phgdh

KW - tumor-associated macrophages

KW - metabolomics

KW - mTOR

KW - cancer

UR - http://www.scopus.com/inward/record.url?scp=85078779147&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.01.011

DO - 10.1016/j.celrep.2020.01.011

M3 - Article

SN - 2211-1247

VL - 30

SP - 1542

EP - 1552

JO - Cell Reports

JF - Cell Reports

IS - 5

M1 - e7

ER -

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

ÖFOS 2012

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