Lactic acid oligomers (OLAs) as prodrug moieties.

J. Kruse, B. Lachmann, R. Lauer, S. Eppacher, Christian Noe

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

    Abstract

    In this paper we propose the use of lactic acid oligomers (OLAs) as prodrug moieties. Two synthetic approaches are presented, on the one hand a non selective oligomerisation of lactic acid and on the other hand a block synthesis to tetramers of lactic acid. Dimers of lactic acid were investigated with respect to their plasma stability and their adsorption to albumine. Ibuprofen was chosen as the first drug for OLAylation. The ester 19 of LA(1)-ibuprofen was evaluated with respect to the degrdn. to human plasma and the adsorption to albumine. All results indicate that lactic acid oligomers are promising prodrug moieties. [on SciFinder(R)]
    OriginalspracheEnglisch
    Seiten (von - bis)93-99
    Seitenumfang7
    FachzeitschriftDie Pharmazie: an international journal of pharmaceutical sciences
    Jahrgang68
    Ausgabenummer2
    DOIs
    PublikationsstatusVeröffentlicht - 2013

    ÖFOS 2012

    • 104015 Organische Chemie
    • 104002 Analytische Chemie

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