Meiotic telomere clustering requires actin for its formation and cohesin for its resolution

Edgar Trelles-Sticken, Caroline Adelfalk, Josef Loidl, Harry Scherthan

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

    Abstract

    In diploid organisms, meiosis reduces the chromosome number by half during the formation of haploid gametes. During meiotic prophase, telomeres transiently cluster at a limited sector of the nuclear envelope (bouquet stage) near the spindle pole body (SPB). Cohesin is a multisubunit complex that contributes to chromosome segregation in meiosis I and II divisions. In yeast meiosis, deficiency for Rec8 cohesin subunit induces telomere clustering to persist, whereas telomere cluster-SPB colocalization is defective. These defects are rescued by expressing the mitotic cohesin Scc1 in rec8? meiosis, whereas bouquet-stage exit is independent of Cdc5 pololike kinase. An analysis of living Saccharomyces cerevisiae meiocytes revealed highly mobile telomeres from leptotene up to pachytene, with telomeres experiencing an actin- but not microtubule-dependent constraint of mobility during the bouquet stage. Our results suggest that cohesin is required for exit from actin polymerization-dependent telomere clustering and for linking the SPB to the telomere cluster in synaptic meiosis. Œ The Rockefeller University Press.
    OriginalspracheEnglisch
    Seiten (von - bis)213-223
    Seitenumfang11
    FachzeitschriftThe Journal of Cell Biology (JCB)
    Jahrgang170
    Ausgabenummer2
    PublikationsstatusVeröffentlicht - 2005

    ÖFOS 2012

    • 1060 Biologie

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