Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3

Alison Gardner; Wei Wu; Steven Thomson; Eva-Maria Zangerl-Plessl; Anna Stary-Weinzinger; Michael C Sanguinetti

doi:10.1124/mol.117.108886

Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3

Alison Gardner
, Wei Wu
, Steven Thomson
, Eva-Maria Zangerl-Plessl
, Anna Stary-Weinzinger
, Michael C Sanguinetti (Korresp. Autor*in)

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Originalsprache	Englisch
Seiten (von - bis)	437-450
Seitenumfang	14
Fachzeitschrift	Molecular Pharmacology
Jahrgang	92
Ausgabenummer	4
DOIs	https://doi.org/10.1124/mol.117.108886
Publikationsstatus	Veröffentlicht - Okt. 2017

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This work was supported by the National Institutes of Health National Heart, Lung, and Blood Institute [Grant R01-HL055236 (to M.C.S.)], the Austrian Science Fund [Grant W1232 (to E.-M.Z.-P. and A.S.-W.)], and Wiener Hochschuljubil\u00E4umsstiftung [Grant H-304013/2014 (to A.S.-W.)]. https://doi.org/10.1124/mol.117.108886. s This article has supplemental material available at molpharm.aspetjournals. org.

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301206 Pharmakologie

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title = "Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3",

keywords = "Animals, Dose-Response Relationship, Drug, Ether-A-Go-Go Potassium Channels, Ginsenosides, Humans, Ion Channel Gating, Protein Structure, Secondary, Xenopus laevis, Journal Article, DOMAIN, MECHANISM, DETERMINANTS, STOICHIOMETRY, INACTIVATION, ACTIVATOR, MUTATIONS, K+ CHANNEL, RESIDUES, POTASSIUM CHANNEL",

author = "Alison Gardner and Wei Wu and Steven Thomson and Eva-Maria Zangerl-Plessl and Anna Stary-Weinzinger and Sanguinetti, \{Michael C\}",

note = "Copyright {\textcopyright} 2017 by The American Society for Pharmacology and Experimental Therapeutics.",

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doi = "10.1124/mol.117.108886",

language = "English",

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AU - Thomson, Steven

AU - Zangerl-Plessl, Eva-Maria

AU - Stary-Weinzinger, Anna

AU - Sanguinetti, Michael C

PY - 2017/10

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KW - Ether-A-Go-Go Potassium Channels

KW - Ginsenosides

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KW - Ion Channel Gating

KW - Protein Structure, Secondary

KW - Xenopus laevis

KW - Journal Article

KW - DOMAIN

KW - MECHANISM

KW - DETERMINANTS

KW - STOICHIOMETRY

KW - INACTIVATION

KW - ACTIVATOR

KW - MUTATIONS

KW - K+ CHANNEL

KW - RESIDUES

KW - POTASSIUM CHANNEL

UR - https://www.scopus.com/pages/publications/85029181007

U2 - 10.1124/mol.117.108886

DO - 10.1124/mol.117.108886

M3 - Article

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SN - 0026-895X

VL - 92

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JO - Molecular Pharmacology

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Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3

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ÖFOS 2012

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