Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum

Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler (Korresp. Autor*in), Marcel Strauss, Martin F.X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.
OriginalspracheEnglisch
Aufsatznummere202400167
Seitenumfang9
FachzeitschriftHelvetica Chimica Acta
Jahrgang108
Ausgabenummer2
Frühes Online-Datum25 Dez. 2024
DOIs
PublikationsstatusVeröffentlicht - Feb. 2025

ÖFOS 2012

  • 104017 Physikalische Chemie
  • 104026 Spektroskopie

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