New insights into an old story: Agrobacterium-induced tumour formation in plants by plant transformation.

Heribert Hirt (Korresp. Autor*in), Andrea Pitzschke

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed


Agrobacterium tumefaciens causes tumour formation in plants. Plant signals induce in the bacteria the expression of a range of virulence (Vir) proteins and the formation of a type IV secretion system (T4SS). On attachment to plant cells, a transfer DNA (T-DNA) and Vir proteins are imported into the host cells through the bacterial T4SS. Through interaction with a number of host proteins, the Vir proteins suppress the host innate immune system and support the transfer, nuclear targeting, and integration of T-DNA into host cell chromosomes. Owing to extensive genetic analyses, the bacterial side of the plant-Agrobacterium interaction is well understood. However, progress on the plant side has only been achieved recently, revealing a highly complex molecular choreography under the direction of the Vir proteins that impinge on multiple processes including transport, transcription, and chromosome status of their host cells.
Seiten (von - bis)1021-1032
FachzeitschriftThe EMBO Journal
PublikationsstatusVeröffentlicht - 2010

ÖFOS 2012

  • 106023 Molekularbiologie