@article{77347624d3a442d896f03b692bdef0be,
title = "Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast",
abstract = "Two rounds of chromosome segregation after only a single round of DNA replication enable the production of haploid gametes from diploid precursors during meiosis. To identify genes involved in meiotic chromosome segregation, we developed an efficient strategy to knock out genes in the fission yeast on a large scale. We used this technique to delete 180 functionally uncharacterized genes whose expression is upregulated during meiosis. Deletion of two genes, sgo1 and mde2, caused massive chromosome missegregation. sgo1 is required for retention of centromeric sister-chromatid cohesion after anaphase I [1-3]. We show here that mde2 is required for formation of the double-strand breaks necessary for meiotic recombination. {\OE}2005 Elsevier Ltd. All rights reserved.",
author = "Juraj Gregan and Rabitsch, {Peter K.} and Ortansa Csutak and Vitaly Latypov and Elisabeth Lehmann and J{\"u}rg Kohli and Kim Nasmyth",
note = "DOI: 10.1016/j.cub.2005.07.059 Coden: CUBLE Affiliations: Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria; Institute of Cell Biology, University of Bern, Baltzer-Strasse 4, CH-3012 Bern, Switzerland; Department of Genetics, University of Bucharest, Aleea Portocalilor, nr. 1-3, 77206 Bucharest, Romania Adressen: Nasmyth, K.; Research Institute of Molecular Pathology; Dr. Bohr-Gasse 7 A-1030 Vienna, Austria; email:
[email protected] Source-File: MFPLUniWienScopus.csv Import aus Scopus: 2-s2.0-24944465648 Importdatum: 07.12.2006 15:11:47 15.01.2009: Datenanforderung 2651 (Import Sachbearbeiter) 15.01.2009: Datenanforderung 2651 (Import Sachbearbeiter)",
year = "2005",
language = "English",
volume = "15",
pages = "1663--1669",
journal = "Current Biology",
issn = "0960-9822",
publisher = "CELL PRESS",
number = "18",
}