TY - JOUR
T1 - Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods
AU - Ungersböck, Johanna
AU - Philippe, Cecile
AU - Haeusler, Daniela
AU - Mitterhauser, Markus
AU - Lanzenberger, Rupert
AU - Dudczak, Robert
AU - Wadsak, Wolfgang
N1 - Accession Number: WOS:000309787100010
PY - 2012
Y1 - 2012
N2 - The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).
AB - The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).
U2 - 10.1016/j.apradiso.2012.08.001
DO - 10.1016/j.apradiso.2012.08.001
M3 - Article
SN - 0969-8043
VL - 70
SP - 2615
EP - 2620
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 11
ER -