Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller; Evelyn Balsano; Samuel Matthias Meier; Ute Jungwirth; Simone Göschl; Alexander Roller; Michael Jakupec; Walter Berger; Bernhard Keppler; Christian G. Hartinger

doi:10.1039/c3cc40432c

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller (Korresp. Autor*in), Evelyn Balsano, Samuel Matthias Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael Jakupec, Walter Berger, Bernhard Keppler, Christian G. Hartinger

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

Organometallic Ru-II, Os-II and Rh-III complexes of lapachol induce apoptosis in human tumour cell lines in the low mu M range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Originalsprache	Englisch
Seiten (von - bis)	3348-3350
Seitenumfang	3
Fachzeitschrift	Chemical Communications
Jahrgang	49
Ausgabenummer	32
DOIs	https://doi.org/10.1039/c3cc40432c
Publikationsstatus	Veröffentlicht - 2013

ÖFOS 2012

104003 Anorganische Chemie
301207 Pharmazeutische Chemie

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10.1039/c3cc40432c

Zitationsweisen

Kandioller, W., Balsano, E., Meier, S. M., Jungwirth, U., Göschl, S., Roller, A., Jakupec, M., Berger, W., Keppler, B., & Hartinger, C. G. (2013). Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chemical Communications, 49(32), 3348-3350. https://doi.org/10.1039/c3cc40432c

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title = "Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity",

abstract = "Organometallic Ru-II, Os-II and Rh-III complexes of lapachol induce apoptosis in human tumour cell lines in the low mu M range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.",

author = "Wolfgang Kandioller and Evelyn Balsano and Meier, {Samuel Matthias} and Ute Jungwirth and Simone G{\"o}schl and Alexander Roller and Michael Jakupec and Walter Berger and Bernhard Keppler and Hartinger, {Christian G.}",

note = "Accession Number: WOS:000316693100022",

year = "2013",

doi = "10.1039/c3cc40432c",

language = "English",

volume = "49",

pages = "3348--3350",

journal = "Chemical Communications",

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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. / Kandioller, Wolfgang (Korresp. Autor*in); Balsano, Evelyn; Meier, Samuel Matthias et al.
in: Chemical Communications, Band 49, Nr. 32, 2013, S. 3348-3350.

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

TY - JOUR

T1 - Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

AU - Kandioller, Wolfgang

AU - Balsano, Evelyn

AU - Meier, Samuel Matthias

AU - Jungwirth, Ute

AU - Göschl, Simone

AU - Roller, Alexander

AU - Jakupec, Michael

AU - Berger, Walter

AU - Keppler, Bernhard

AU - Hartinger, Christian G.

N1 - Accession Number: WOS:000316693100022

PY - 2013

Y1 - 2013

N2 - Organometallic Ru-II, Os-II and Rh-III complexes of lapachol induce apoptosis in human tumour cell lines in the low mu M range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

AB - Organometallic Ru-II, Os-II and Rh-III complexes of lapachol induce apoptosis in human tumour cell lines in the low mu M range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

U2 - 10.1039/c3cc40432c

DO - 10.1039/c3cc40432c

M3 - Article

SN - 1359-7345

VL - 49

SP - 3348

EP - 3350

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Abstract

ÖFOS 2012

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