Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline: Synthesis, structures and antiproliferative activity

A. Gavriluta; M. Novak; J.B. Tommasino; S.M. Meier; M.A. Jakupec; D. Luneau; V.B. Arion

doi:10.1002/zaac.201300054

Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline: Synthesis, structures and antiproliferative activity

A. Gavriluta, M. Novak, J.B. Tommasino, S.M. Meier, M.A. Jakupec, D. Luneau (Korresp. Autor*in), V.B. Arion (Korresp. Autor*in)

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

The reactions of [Os(NO)Cl] with glycine (GlyH), picolinic acid (PicoH), L-proline (L-ProH) and D-proline (D-ProH) afforded four novel complexes of the general formula [Os(NO)Cl(AA)], where AA = Gly, Pico, L-Pro and D-Pro, respectively. X-ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer(Cl), trans(NO, O)-[Os(NO)Cl (AA)]. Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.

Originalsprache	Englisch
Seiten (von - bis)	1590-1597
Seitenumfang	8
Fachzeitschrift	Zeitschrift für Anorganische und Allgemeine Chemie
Jahrgang	639
Ausgabenummer	8-9
DOIs	https://doi.org/10.1002/zaac.201300054
Publikationsstatus	Veröffentlicht - 1 Juli 2013

ÖFOS 2012

104003 Anorganische Chemie
301305 Medizinische Chemie

UN SDGs

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10.1002/zaac.201300054

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title = "Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline: Synthesis, structures and antiproliferative activity",

abstract = "The reactions of [Os(NO)Cl] with glycine (GlyH), picolinic acid (PicoH), L-proline (L-ProH) and D-proline (D-ProH) afforded four novel complexes of the general formula [Os(NO)Cl(AA)], where AA = Gly, Pico, L-Pro and D-Pro, respectively. X-ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer(Cl), trans(NO, O)-[Os(NO)Cl (AA)]. Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.",

author = "A. Gavriluta and M. Novak and J.B. Tommasino and S.M. Meier and M.A. Jakupec and D. Luneau and V.B. Arion",

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T1 - Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline

T2 - Synthesis, structures and antiproliferative activity

AU - Gavriluta, A.

AU - Novak, M.

AU - Tommasino, J.B.

AU - Meier, S.M.

AU - Jakupec, M.A.

AU - Luneau, D.

AU - Arion, V.B.

N1 - Accession Number: WOS:000330180900038

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The reactions of [Os(NO)Cl] with glycine (GlyH), picolinic acid (PicoH), L-proline (L-ProH) and D-proline (D-ProH) afforded four novel complexes of the general formula [Os(NO)Cl(AA)], where AA = Gly, Pico, L-Pro and D-Pro, respectively. X-ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer(Cl), trans(NO, O)-[Os(NO)Cl (AA)]. Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.

AB - The reactions of [Os(NO)Cl] with glycine (GlyH), picolinic acid (PicoH), L-proline (L-ProH) and D-proline (D-ProH) afforded four novel complexes of the general formula [Os(NO)Cl(AA)], where AA = Gly, Pico, L-Pro and D-Pro, respectively. X-ray diffraction studies have revealed that in all cases the same isomer type from three theoretically possible, has been isolated, namely mer(Cl), trans(NO, O)-[Os(NO)Cl (AA)]. Spectroscopic and electrochemical properties, behavior in aqueous solution and antiproliferative activity in three human cancer cell lines are also reported.

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Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline: Synthesis, structures and antiproliferative activity

Abstract

ÖFOS 2012

UN SDGs

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