p38 links RAS to GATA2

Christian Baumgartner; Manuela Baccarini

doi:10.15252/embr.201439309

p38 links RAS to GATA2

Christian Baumgartner, Manuela Baccarini

Department für Mikrobiologie, Immunbiologie und Genetik

Veröffentlichungen: Beitrag in Fachzeitschrift › Short Communication › Peer Reviewed

Abstract

More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation. Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic link between RAS and GATA2 had not been identified. A paper in this issue of EMBO reports closes this gap showing that GATA2 can be activated by p38 in RAS-transformed cells [3]..

Originalsprache	Englisch
Seiten (von - bis)	912-913
Seitenumfang	2
Fachzeitschrift	EMBO Reports
Jahrgang	15
Ausgabenummer	9
DOIs	https://doi.org/10.15252/embr.201439309
Publikationsstatus	Veröffentlicht - Sept. 2014

ÖFOS 2012

106013 Genetik

UN SDGs

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10.15252/embr.201439309

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title = "p38 links RAS to GATA2",

abstract = "More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation. Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic link between RAS and GATA2 had not been identified. A paper in this issue of EMBO reports closes this gap showing that GATA2 can be activated by p38 in RAS-transformed cells [3]..",

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AU - Baccarini, Manuela

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AB - More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation. Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic link between RAS and GATA2 had not been identified. A paper in this issue of EMBO reports closes this gap showing that GATA2 can be activated by p38 in RAS-transformed cells [3]..

KW - HEMATOPOIETIC STEM-CELLS

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DO - 10.15252/embr.201439309

M3 - Short communication

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JO - EMBO Reports

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p38 links RAS to GATA2

Abstract

ÖFOS 2012

UN SDGs

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