Polygenic adaptation: a unifying framework to understand positive selection

Neda Barghi, Joachim Hermisson (Korresp. Autor*in), Christian Schlötterer (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftReviewPeer Reviewed

Abstract

Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics — heterogeneity among loci and non-parallelism between replicated populations — are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.
OriginalspracheEnglisch
Seiten (von - bis)769-781
Seitenumfang13
FachzeitschriftNature Reviews. Genetics
Jahrgang21
Ausgabenummer12
Frühes Online-Datum29 Juni 2020
DOIs
PublikationsstatusVeröffentlicht - Dez. 2020

ÖFOS 2012

  • 106013 Genetik
  • 106033 Phylogenie

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