TY - JOUR
T1 - Polygenic adaptation
T2 - a unifying framework to understand positive selection
AU - Barghi, Neda
AU - Hermisson, Joachim
AU - Schlötterer, Christian
N1 - Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/12
Y1 - 2020/12
N2 - Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics — heterogeneity among loci and non-parallelism between replicated populations — are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.
AB - Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics — heterogeneity among loci and non-parallelism between replicated populations — are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.
KW - ARABIDOPSIS-THALIANA
KW - EXPERIMENTAL EVOLUTION
KW - INFINITESIMAL MODEL
KW - NATURAL-SELECTION
KW - PARALLEL EVOLUTION
KW - POECILIA-RETICULATA
KW - QUANTITATIVE TRAIT
KW - STABILIZING SELECTION
KW - STANDING GENETIC-VARIATION
KW - TRANSPOSON INSERTION
UR - http://www.scopus.com/inward/record.url?scp=85087112137&partnerID=8YFLogxK
U2 - 10.1038/s41576-020-0250-z
DO - 10.1038/s41576-020-0250-z
M3 - Review
C2 - 32601318
SN - 1471-0056
VL - 21
SP - 769
EP - 781
JO - Nature Reviews. Genetics
JF - Nature Reviews. Genetics
IS - 12
ER -