Quantitative Structural Rearrangement of HIV-1 reverse transcriptase on binding to non-nucleoside inhibitors

Luckhana Lawtrakul, Anton Beyer, Supa Hannongbua, Karl Peter Wolschann

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

The crystal structures of HIV-1 reverse transcriptase (RT) and some of its inhibitor complexes have been compared quantitatively with respect to backbone and side chain dihedral angles. Furthermore distances between inhibitor molecules and surrounding amino acids have been analyzed in detail. The calculation of the conformation for all structures allows us to determine quantitative structural changes of HIV-1 RT on binding to NNIs or to RNA/DNA. ΠSpringer-Verlag 2004.
OriginalspracheEnglisch
Seiten (von - bis)1033-1046
Seitenumfang14
FachzeitschriftMonatshefte für Chemie
Jahrgang135
Ausgabenummer8
PublikationsstatusVeröffentlicht - 2004

ÖFOS 2012

  • 1040 Chemie

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