Reshaping the optical dimension in optogenetics

Alipasha Vaziri, Valentina Emiliani

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed


Optogenetics has been revolutionizing circuit neuroscience in the last few years. Optical methods combined with genetics and molecular techniques have provided new tools for stimulation of neurons, which hold great promise to provide a solution to the circuit mapping problem and more generally provide us with the ability to artificially control the natural stimulus space. Nevertheless, until very recently almost all applications of optogenetics have been based on relatively simple optical schemes mainly used for inducing population activity in neuronal assembles. In this context, alternative optical schemes that enhance the spatial or temporal resolution of excitation and allow for flexible and arbitrary generation of light patterns have all synergetic impact on the development of new optogenetic actuators. In the following we discuss and compare the main new optical techniques that have become available in the recent years. Their respective strengths and limitations as well as their application to different biological contexts are illustrated
Seiten (von - bis)128-133
FachzeitschriftCurrent Opinion in Neurobiology
PublikationsstatusVeröffentlicht - 2012

ÖFOS 2012

  • 104021 Strukturchemie