Resveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells

Jason D. Kenealey, Lalita Subramanian, Paul R. Van Ginkel, Soesiawati Darjatmoko, Mary J. Lindstrom, Veronika Somoza, Sunil K. Ghosh, Richard P. Hsung, Glen S. Kwon, Kevin W. Eliceiri, Daniel M. Albert, Arthur S. Polans (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

Resveratrol, a nontoxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly metabolized, mainly to its glucuronidated and sulfated derivatives. This study demonstrates that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a rise in [Ca2+](i), and ultimately leads to a decrease in tumor cell viability. A new water-soluble resveratrol formulation was delivered directly at the site of the tumor in a neuroblastoma mouse model. The amount of unmodified resveratrol associated with the tumor increased more than 1000-fold. The increase of unmodified resveratrol associated with the tumor resulted in tumor regression. The number of residual tumor cells that remained viable also decreased as the ratio of the metabolites relative to unmodified resveratrol declined.
OriginalspracheEnglisch
Seiten (von - bis)4979-4986
Seitenumfang8
FachzeitschriftJournal of Agricultural and Food Chemistry
Jahrgang59
Ausgabenummer9
PublikationsstatusVeröffentlicht - 2011

ÖFOS 2012

  • 301207 Pharmazeutische Chemie
  • 303009 Ernährungswissenschaften

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