RNA editing level in the mouse is determined by the genomic repeat repertoire

Yossef Neeman, Erez Y. Levanon, Franz-Michael Jantsch, Eli Eisenberg

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

    Abstract

    A-to-I RNA editing is the conversion of adenosine to inosine in double-stranded cellular and viral RNAs. Recently, abundant editing of human transcripts affecting thousands of genes has been reported. Most editing sites are confined to the primate-specific Alu repeats. Notably, the editing level in mouse was shown to be much lower. In order to find the reason for this dramatic difference, here we identify editing sites within mouse repeats and analyze the sequence properties required for RNA editing. Our results show that the overall rate of RNA editing is determined by specific properties of different repeat families such as abundance, length, and divergence. We show that the striking difference in editing levels between human and mouse is mostly due to the higher divergence of the different mouse repeats. Published by Cold Spring Harbor Laboratory Press. Copyright Œ 2006 RNA Society.
    OriginalspracheEnglisch
    Seiten (von - bis)1802-1809
    Seitenumfang8
    FachzeitschriftRNA
    Jahrgang12
    Ausgabenummer10
    PublikationsstatusVeröffentlicht - 2006

    ÖFOS 2012

    • 1060 Biologie

    Fingerprint

    Untersuchen Sie die Forschungsthemen von „RNA editing level in the mouse is determined by the genomic repeat repertoire“. Zusammen bilden sie einen einzigartigen Fingerprint.

    Zitationsweisen