TY - JOUR
T1 - RNA editing level in the mouse is determined by the genomic repeat repertoire
AU - Neeman, Yossef
AU - Levanon, Erez Y.
AU - Jantsch, Franz-Michael
AU - Eisenberg, Eli
N1 - DOI: 10.1261/rna.165106
Coden: RNARF
Affiliations: Compugen Ltd., Tel-Aviv 69512, Israel; Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel; Department of Pediatric Hemato-Oncology, Safra Children's Hospital, Tel Aviv University, Tel Aviv, Israel; Max F. Perutz Laboratories, Department of Chromosome Biology, University of Vienna, A-1030 Vienna, Austria; School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel; School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel
Adressen: Eisenberg, E.; School of Physics and Astronomy; Tel Aviv University Tel Aviv 69978, Israel; email: [email protected]
Source-File: MFPLUniWienScopus.csv
Import aus Scopus: 2-s2.0-33749256772
Importdatum: 07.12.2006 15:11:00
15.01.2009: Datenanforderung 2651 (Import Sachbearbeiter)
15.01.2009: Datenanforderung 2651 (Import Sachbearbeiter)
PY - 2006
Y1 - 2006
N2 - A-to-I RNA editing is the conversion of adenosine to inosine in double-stranded cellular and viral RNAs. Recently, abundant editing of human transcripts affecting thousands of genes has been reported. Most editing sites are confined to the primate-specific Alu repeats. Notably, the editing level in mouse was shown to be much lower. In order to find the reason for this dramatic difference, here we identify editing sites within mouse repeats and analyze the sequence properties required for RNA editing. Our results show that the overall rate of RNA editing is determined by specific properties of different repeat families such as abundance, length, and divergence. We show that the striking difference in editing levels between human and mouse is mostly due to the higher divergence of the different mouse repeats. Published by Cold Spring Harbor Laboratory Press. Copyright Œ 2006 RNA Society.
AB - A-to-I RNA editing is the conversion of adenosine to inosine in double-stranded cellular and viral RNAs. Recently, abundant editing of human transcripts affecting thousands of genes has been reported. Most editing sites are confined to the primate-specific Alu repeats. Notably, the editing level in mouse was shown to be much lower. In order to find the reason for this dramatic difference, here we identify editing sites within mouse repeats and analyze the sequence properties required for RNA editing. Our results show that the overall rate of RNA editing is determined by specific properties of different repeat families such as abundance, length, and divergence. We show that the striking difference in editing levels between human and mouse is mostly due to the higher divergence of the different mouse repeats. Published by Cold Spring Harbor Laboratory Press. Copyright Œ 2006 RNA Society.
M3 - Article
SN - 1355-8382
VL - 12
SP - 1802
EP - 1809
JO - RNA
JF - RNA
IS - 10
ER -