RNA Folding Algorithms with G-Quadruplexes

Ronny Lorenz, Stephan H F Bernhart, Fabian Externbrink, Jing Qin, Christian Höner zu Siederdissen, Fabian Amman, Ivo Hofacker, Peter Stadler

Veröffentlichungen: Beitrag in BuchBeitrag in Konferenzband

Abstract

G-quadruplexes are abundant locally stable structural elements in nucleic acids. The combinatorial theory of RNA structures and the dynamic programming algorithms for RNA secondary structure prediction are extended here to incorporate G-quadruplexes using a simple but plausible energy model. With preliminary energy parameters we find that the overwhelming majority of putative quadruplex-forming sequences in the human genome are likely to fold into canonical secondary structures instead.
OriginalspracheEnglisch
TitelAdvances in Bioinformatics and Computational Biology; 7th Brazilian Symposium on Bioinformatics, BSB 2012, Campo Grande, Brazil, August 15-17, 2012. Proceedings
Herausgeber (Verlag)Springer-Verlag Berlin
Seiten49-60
Seitenumfang12
DOIs
PublikationsstatusVeröffentlicht - 2012

Publikationsreihe

ReiheLecture Notes in Computer Science
ISSN0302-9743

ÖFOS 2012

  • 106005 Bioinformatik

Zitationsweisen