Abstract
The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.
Originalsprache | Englisch |
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Seiten (von - bis) | 611-614 |
Seitenumfang | 4 |
Fachzeitschrift | Chemical Communications |
Jahrgang | 54 |
Ausgabenummer | 6 |
DOIs | |
Publikationsstatus | Veröffentlicht - 18 Jan. 2018 |
Extern publiziert | Ja |
ÖFOS 2012
- 104003 Anorganische Chemie
- 104002 Analytische Chemie