Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics

Margot N Wenzel, Samuel M Meier-Menches, Thomas L Williams, Eberard Rämisch, Giampaolo Barone, Angela Casini

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.

OriginalspracheEnglisch
Seiten (von - bis)611-614
Seitenumfang4
FachzeitschriftChemical Communications
Jahrgang54
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - 18 Jan. 2018
Extern publiziertJa

ÖFOS 2012

  • 104003 Anorganische Chemie
  • 104002 Analytische Chemie

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