Skin-compatible lecithin drug delivery systems for fluconazole: effect of phosphatidylethanolamine and oleic acid on skin permeation

Sonja Höller, Victoria Klang, Claudia Valenta (Korresp. Autor*in)

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed


    The purpose of the present study was to evaluate skin compatible drug delivery systems for fluconazole. Pseudo-ternary phase diagrams were constructed composed of different soybean lecithins/oil/isopropanol and water. The role of the various lecithin compositions is expressed in different resulting isotropic areas. Based on these phase diagrams two systems were chosen as drug delivery vehicle for fluconazole. On one hand the influence of phosphatidylethanolamine and on the other hand the influence of the oil component was investigated on the skin permeation of fluconazole. The more phosphatidylethanolamine the higher was the fluconazole skin permeation independent of the hydrophilicity of the system. The influence of oleic acid and isopropylmyristate as an oil component resulted in a preference of penetration enhancing effect of the oleic acid containing microemulsion
    Seiten (von - bis)587-591
    FachzeitschriftJournal of Pharmacy and Pharmacology : JPP; an international journal of pharmaceutical science
    PublikationsstatusVeröffentlicht - 2008

    ÖFOS 2012

    • 301209 Pharmazie
    • 106006 Biophysik