Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

Thomas Erker; Maria Galanski; Christian Studenik

doi:10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

Thomas Erker, Maria Galanski, Christian Studenik

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

Originalsprache	Englisch
Seiten (von - bis)	58-62
Seitenumfang	5
Fachzeitschrift	Archiv der Pharmazie
Jahrgang	333
Ausgabenummer	2-3
DOIs	https://doi.org/10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L
Publikationsstatus	Veröffentlicht - 2000

ÖFOS 2012

3012 Pharmazie, Pharmakologie, Toxikologie

Zugriff auf Dokument

10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

Zitationsweisen

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title = "Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities",

abstract = "In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.",

author = "Thomas Erker and Maria Galanski and Christian Studenik",

note = "DOI: 10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L Coden: ARPMA Affiliations: Inst. of Pharmaceutical Chemistry, University of Vienna, Althanstra{\ss}e 14, A-1090 Vienna, Austria; Inst. of Pharmacology and Toxicology, University of Vienna, Althanstra{\ss}e 14, A-1090 Vienna, Austria Source-File: MedPharmChemScopus_iso.csv Import aus Scopus: 2-s2.0-0034117203 Importdatum: 22.11.2006 17:14:51 09.08.2007: Datenanforderung 1812 (Import Sachbearbeiter) 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)",

year = "2000",

doi = "10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L",

language = "English",

volume = "333",

pages = "58--62",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

number = "2-3",

}

Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities. / Erker, Thomas; Galanski, Maria ; Studenik, Christian.

in: Archiv der Pharmazie, Band 333, Nr. 2-3, 2000, S. 58-62.

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

TY - JOUR

T1 - Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19([1]): Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities

AU - Erker, Thomas

AU - Galanski, Maria

AU - Studenik, Christian

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PY - 2000

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AB - In this study novel substituted 6-benzyl-thieno[2,3-b][1,4]thiazines with an urea moiety were synthesized. Structural modifications of the amino side chain were carried out with the aim of finding tissue specific compounds. The effects on papillary muscles, right atria, aortic strips, and terminal ilea were investigated. Compounds 10c and 10d showed the most potent negative inotropic effect. The calcium antagonism of all derivatives occurred in a non-competitive manner, which may indicate that they also have potassium channel opening activities.

U2 - 10.1002/(SICI)1521-4184(200002)333:2/3<58::AID-ARDP58>3.0.CO;2-L

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