Synthesis and biological activity of thienodiltiazem in isolated heart muscle preparations of guinea pigs

Norbert Handler; Thomas Erker; Rosa Lemmens; Christian Studenik

Synthesis and biological activity of thienodiltiazem in isolated heart muscle preparations of guinea pigs

Norbert Handler, Thomas Erker (Korresp. Autor*in), Rosa Lemmens, Christian Studenik

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.

Originalsprache	Englisch
Seiten (von - bis)	757-761
Seitenumfang	5
Fachzeitschrift	Arzneimittel-Forschung
Ausgabenummer	12
Publikationsstatus	Veröffentlicht - 2007

ÖFOS 2012

301206 Pharmakologie
301207 Pharmazeutische Chemie

Zitationsweisen

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title = "Synthesis and biological activity of thienodiltiazem in isolated heart muscle preparations of guinea pigs",

abstract = "The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.",

author = "Norbert Handler and Thomas Erker and Rosa Lemmens and Christian Studenik",

note = "09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)",

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AU - Handler, Norbert

AU - Erker, Thomas

AU - Lemmens, Rosa

AU - Studenik, Christian

N1 - 09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)

PY - 2007

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N2 - The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.

AB - The new compound thienodiltiazem was synthesized and investigated regarding structure-activity relations and calcium antagonistic properties. Isometric contraction force was measured in guinea-pig papillary muscles and chronotropic activity was studied in right atria of guinea pigs. Compared to the parent drug diltiazem (CAS 42399-41-7) the thieno derivative had a more potent negative chronotropic effect on spontaneously beating right atria and a more potent inotropic effect on papillary muscles. The negative inotropic action was reversed by increasing the extracellular calcium concentration.

M3 - Article

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EP - 761

JO - Arzneimittel-Forschung

JF - Arzneimittel-Forschung

SN - 0004-4172

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