Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine) platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand

Mathea Sophia Galanski (Korresp. Autor*in), Susanna Slaby, Michael Jakupec, Bernhard Keppler

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

In order to develop platinum complexes with selective activity in primary and secondary bonemalignancies and with the aim to optimize antitumor activity, platinum(II) complexes withaminotris(methylenephosphonic acid) as bone-seeking (osteotropic) ligand have been synthesized,characterized and tested in the cisplatin-sensitive ovarian carcinoma cell line CH1. As non-leaving diamineligands, which are decisive for the cellular processing of DNA adducts, cis-R,S-cyclohexane-1,2-diamine,trans-S,S-cyclohexane-1,2-diamine and trans-R,R-cyclohexane-1,2-diamine have been used, resulting incomplexes 1, 2, and 3, respectively. The cytotoxicity of the complexes under investigation decreases in theorder 3 > 2 > 1 which is in accord with structure-activity relationships with other (cyclohexane-1,2-diamine)platinum(II) and platinum(IV) complexes: Both trans complexes (2 and 3) display a higher in vitropotency than the corresponding cis isomer (I), with the trans-R,R isomer (3) being the most active in thisseries. In comparison to the analogous (cyclohexane-1,2-diamine) platinum(II) complexes withbis(phosphonomethyl)aminoacetic acid as osteotropic carrier ligand, the cytotoxicity of 1-3 was found to be1.5 - 2 fold higher, which is explainable by a different coordination mode of the phosphonic acid ligands(acetato versus phosphonato).
OriginalspracheEnglisch
Seiten (von - bis)179-190
Seitenumfang12
FachzeitschriftBioinorganic Chemistry and Applications
Jahrgang3
Ausgabenummer3-4
DOIs
PublikationsstatusVeröffentlicht - 2005

ÖFOS 2012

  • 104003 Anorganische Chemie

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