The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions

M. P. Sullivan (Korresp. Autor*in), H. U. Holtkamp, S. M. Meier, C. G. Hartinger

Veröffentlichungen: Beitrag in BuchBeitrag in Buch/SammelbandPeer Reviewed

Abstract

The mode of action of medically relevant coordination and organometallic compounds in a biological environment is crucially dependent on their interactions with biological molecules. Since the discovery of cisplatin, a wide variety of metal complexes have been designed for the treatment of cancer and other diseases as well as for diagnostic purposes. In this chapter, we review the binding events inorganic compounds undergo from administration to the biological target with a special emphasis on the strengths and weaknesses of the methods employed for these studies. We have focused on compounds that are at an advanced preclinical development stage, undergo clinical trials or are in clinical use.
OriginalspracheEnglisch
TitelInorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells
Herausgeber (Verlag)Elsevier
Seiten355-386
Seitenumfang32
ISBN (elektronisch)9780128038871
ISBN (Print)9780128038147
DOIs
PublikationsstatusVeröffentlicht - 6 Jan. 2017

ÖFOS 2012

  • 104003 Anorganische Chemie
  • 104002 Analytische Chemie
  • 301904 Krebsforschung

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