The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination

Claudia-Anna Kerzendorfer, J Vignard, Andrea Pedrosa Harand, Tanja Siwiec, Svetlana A. Akimcheva, S Jolivet, R Sablowski, Sue Armstrong, Dieter Schweizer, R Mercier, Peter Schlögelhofer

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

    Abstract

    Mnd1 has recently been identified in yeast as a key player in meiotic recombination. Here we describe the identification and functional characterisation of the Arabidopsis homologue, AtMND1, which is essential for male and female meiosis and thus for plant fertility. Although axial elements are formed normally, sister chromatid cohesion is established and recombination initiation appears to be unaffected in mutant plants, chromosomes do not synapse. During meiotic progression, a mass of entangled chromosomes, interconnected by chromatin bridges, and severe chromosome fragmentation are observed. These defects depend on the presence of SPO11-1, a protein that initiates recombination by catalysing DNA double-strand break (DSB) formation. Furthermore, we demonstrate that the AtMND1 protein interacts with AHP2, the Arabidopsis protein closely related to budding yeast Hop2. These data demonstrate that AtMND1 plays a key role in homologous synapsis and in DSB repair during meiotic recombination.
    OriginalspracheEnglisch
    Seiten (von - bis)2486-2496
    Seitenumfang11
    FachzeitschriftJournal of Cell Science
    Jahrgang119
    Ausgabenummer12
    PublikationsstatusVeröffentlicht - 2006

    ÖFOS 2012

    • 1060 Biologie

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