The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Yinhua Huang, Yingrui Li, David W. Burt, Hualan Chen, Yong Zhang, Wubin Qian, Heebal Kim, Shangquan Gan, Yiqiang Zhao, Jianwen Li, Kang Yi, Huapeng Feng, Pengyang Zhu, Bo Li, Qiuyue Liu, Suan Fairley, Katharine E. Magor, Zhenlin Du, Xiaoxiang Hu, Laurie GoodmanHakim Tafer, Alain Vignal, Taeheon Lee, Kyu-Won Kim, Zheya Sheng, Yang An, Steve Searle, Javier Herrero, Martien A. M. Groenen, Richard P. M. A. Crooijmans, Thomas Faraut, Qingle Cai, Robert G. Webster, Jerry R. Aldridge, Wesley C. Warren, Sebastian Bartschat, Stephanie Kehr, Manja Marz, Peter F. Stadler, Jacqueline Smith, Robert H. S. Kraus, Yaofeng Zhao, Liming Ren, Jing Fei, Mireille Morisson, Pete Kaiser, Darren K. Griffin, Man Rao, Frederique Pitel, Jun Wang (Korresp. Autor*in), Ning Li

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
OriginalspracheEnglisch
Seiten (von - bis)776-783
FachzeitschriftNature Genetics
Jahrgang45
Ausgabenummer7
DOIs
PublikationsstatusVeröffentlicht - Juli 2013

ÖFOS 2012

  • 301305 Medizinische Chemie
  • 106005 Bioinformatik

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