The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

Anna Bytzek, Michael Reithofer, Mathea Sophia Galanski, Michael Größl, Bernhard Keppler, Christian Hartinger (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

MEEKC is a powerful electrodriven separation technique with many applications in different disciplines, including medicinal chemistry; however, up to now the coupling to highly sensitive and selective MS detectors was limited due to the ion suppressive effect of the commonly used surfactant SDS. Herein, the first example of the coupling of MEEKC to ICP-MS is presented and an MEEKC method for the separation of Pt(II) and Pt(IV) anticancer drugs and drug candidates was developed. Different compositions of microemulsions were evaluated and the data were compared with those collected with standard ultraviolet/visible (UV/vis) spectroscopy detection. The MEEKC-ICP-MS system was found to be more sensitive than MEEKC-UV/vis and the analysis of UV/vis silent compounds is now achievable. The migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their different chemical structures.
OriginalspracheEnglisch
Seiten (von - bis)1144-1150
Seitenumfang7
FachzeitschriftElectrophoresis
Jahrgang31
Ausgabenummer7
DOIs
PublikationsstatusVeröffentlicht - 2010

ÖFOS 2012

  • 104003 Anorganische Chemie
  • 301305 Medizinische Chemie
  • 104002 Analytische Chemie

Zitationsweisen