The nuclear envelope protein matefin/SUN 1 is required for homologous pairing in C. elegans meiosis

Alexandra Penkner, Lois Tang, Maria Novatchkova, Markus Ladurner, Alexandra Fridkin, Yosef Gruenbaum, Dieter Schweizer, Josef Loidl, Verena Jantsch (Korresp. Autor*in)

Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed

Abstract

We identify a highly specific mutation (jf18) in the Caenorhabditis elegans nuclear envelope protein matefin MTF-1/SUN-1 that provides direct evidence for active involvement of the nuclear envelope in homologous chromosome pairing in C. elegans meiosis. The reorganization of chromatin in early meiosis is disrupted in mtf-1/sun-1(jf18) gonads, concomitant with the absence of presynaptic homolog alignment. Synapsis is established precociously and nonhomologously. Wild-type leptotene/zygotene nuclei show patch-like aggregations of the ZYG-12 protein, which fail to develop in mtf-1/sun-1(jf18) mutants. These patches remarkably colocalize with a component of the cis-acting chromosomal pairing center (HIM-8) rather than the centrosome. Our data on this mtf-1/sun-1 allele challenge the previously postulated role of the centrosome/spindle organizing center in chromosome pairing, and clearly support a role for MTF-1/SUN-1 in meiotic chromosome reorganization and in homolog recognition, possibly by mediating local aggregation of the ZYG-12 protein in meiotic nuclei.
OriginalspracheEnglisch
Seiten (von - bis)873-885
Seitenumfang13
FachzeitschriftDevelopmental Cell
Jahrgang12
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - Juni 2007

ÖFOS 2012

  • 106052 Zellbiologie

Fingerprint

Untersuchen Sie die Forschungsthemen von „The nuclear envelope protein matefin/SUN 1 is required for homologous pairing in C. elegans meiosis“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitationsweisen