The role of hedgehog signaling in the development of the zebrafish visual system.

Carl J. Neumann (Korresp. Autor*in), Jochen Stadler, Alena Shkumatava

    Veröffentlichungen: Beitrag in FachzeitschriftArtikelPeer Reviewed


    The vertebrate visual system is a region of the nervous system that is characterized by relative simplicity, and its development has hence been studied intensively, to serve as a paradigm for the rest of the central nervous system. The zebrafish model organism offers an impressive array of tools to dissect this process experimentally, and in recent years has helped to significantly deepen our understanding of the development of the visual system. A number of these studies have focused on the role of the Hedgehog family of secreted signaling molecules in eye development, and this is the main topic of this review. Hedgehog signaling plays an important role in all major steps of visual system development, starting with the regionalization of the eye primordium into proximal and distal territories, continuing with the control of cellular differentiation in the retina, and ending with the guidance of axonal projections from the retina to the optic centers of the brain.
    Seiten (von - bis)346-351
    FachzeitschriftDevelopmental Science
    PublikationsstatusVeröffentlicht - 2004

    ÖFOS 2012

    • 106013 Genetik