Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABA_A receptors by two distinct mechanisms

Pharmacology, Toxicology and Pharmaceutical Science

• 4 Aminobutyric Acid 50%
• Antidepressant 100%
• Antipsychotic 50%
• Antipsychotic Drug 25%
• Binding Site 50%
• Chlorpromazine 75%
• Clozapine 75%
• Radioligand 25%
• Receptor 100%
• Receptor Subtype 100%
• Receptor Subunit 25%
• Therapeutic Effect 25%
• Xenopus laevis 25%

Neuroscience

• Antidepressant 100%
• Antipsychotic 42%
• Binding Site 28%
• Chlorpromazine 42%
• Clozapine 42%
• GABAA Receptor 100%
• Gamma-Aminobutyric Acid 28%
• Hippocampus 14%
• Radioligand 14%
• Receptor Subtype 57%
• Receptor Subunit 14%
• Voltage Clamp 14%