Type I Interferons in Immune Defense Against Streptococci

Pavel Kovarik (Korresp. Autor*in), Virginia Castiglia, Janos Marton

Veröffentlichungen: Beitrag in BuchBeitrag in Buch/Sammelband


Infections with Streptococcus pneumoniae, Group A Streptococcus (GAS), and Group B Streptococcus (GBS) are among the most frequent bacterial infections in humans and major causes of diseases. Immune responses against streptococci include the induction of type I interferons (IFNs), which are immunomodulatory cytokines with well-established antiviral functions, but ambiguous roles in bacterial infections. Studies of streptococcal infections further highlight the importance of type I IFN signaling in host defense against bacterial pathogens. We discuss the complexity of type I IFN induction by streptococcal ligands and their engagement in stimulating innate immune receptors. Furthermore, we elaborate on the broad physiological role and different impacts of type I IFN signaling on the outcome of streptococcal infections and influenza virus coinfections.
TitelBacterial Activation of Type I Interferons
Redakteure*innenDane Parker
Herausgeber (Verlag)Springer
ISBN (elektronisch)978-3-319-09498-4
ISBN (Print)3319094971, 9783319094977
PublikationsstatusVeröffentlicht - 2014

ÖFOS 2012

  • 301902 Immunologie
  • 106022 Mikrobiologie
  • 303020 Medizinische Mikrobiologie