Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes

Sureshbabu Mangali; Audesh Bhat; Kirtikumar Jadhav; Jaspreet Kalra; Dharmarajan Sriram; Venkata Vamsi Krishna Venuganti; Arti Dhar

doi:10.1016/j.bcp.2020.113948

Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes

Sureshbabu Mangali, Audesh Bhat, Kirtikumar Jadhav, Jaspreet Kalra, Dharmarajan Sriram, Venkata Vamsi Krishna Venuganti, Arti Dhar (Korresp. Autor*in)

Institut für Biologische Chemie

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Originalsprache	Englisch
Aufsatznummer	113948
Seitenumfang	12
Fachzeitschrift	Biochemical Pharmacology
Jahrgang	177
DOIs	https://doi.org/10.1016/j.bcp.2020.113948
Publikationsstatus	Veröffentlicht - Juli 2020

ÖFOS 2012

106002 Biochemie
301206 Pharmakologie

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.1016/j.bcp.2020.113948

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@article{05d59452865b43adadcc307538e3e4bc,

title = "Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes",

keywords = "PKR, Glucolipotoxicity, PKR inhibitor, Diabetic cardiomyopathy, OXIDATIVE STRESS, INDUCED APOPTOSIS, ACTIVATION, GLUCOSE, INHIBITION, PALMITATE, OXYGEN, PHOSPHORYLATION, MECHANISMS, PROTECTS",

author = "Sureshbabu Mangali and Audesh Bhat and Kirtikumar Jadhav and Jaspreet Kalra and Dharmarajan Sriram and Venuganti, {Venkata Vamsi Krishna} and Arti Dhar",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

doi = "10.1016/j.bcp.2020.113948",

language = "English",

volume = "177",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

TY - JOUR

T1 - Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes

AU - Mangali, Sureshbabu

AU - Bhat, Audesh

AU - Jadhav, Kirtikumar

AU - Kalra, Jaspreet

AU - Sriram, Dharmarajan

AU - Venuganti, Venkata Vamsi Krishna

AU - Dhar, Arti

PY - 2020/7

Y1 - 2020/7

KW - PKR

KW - Glucolipotoxicity

KW - PKR inhibitor

KW - Diabetic cardiomyopathy

KW - OXIDATIVE STRESS

KW - INDUCED APOPTOSIS

KW - ACTIVATION

KW - GLUCOSE

KW - INHIBITION

KW - PALMITATE

KW - OXYGEN

KW - PHOSPHORYLATION

KW - MECHANISMS

KW - PROTECTS

UR - http://www.scopus.com/inward/record.url?scp=85083339743&partnerID=8YFLogxK

U2 - 10.1016/j.bcp.2020.113948

DO - 10.1016/j.bcp.2020.113948

M3 - Article

VL - 177

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

M1 - 113948

ER -