Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry

Mireia Urpi-Sarda; Olga Jauregui; Rosa M. Lamuela-Raventos; Walter Jäger; Michaela Böhmdorfer; Maria-Isabel Covas; Cristina Andres-Lacueva

Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry

Mireia Urpi-Sarda
, Olga Jauregui
, Rosa M. Lamuela-Raventos
, Walter Jäger
, Michaela Böhmdorfer
, Maria-Isabel Covas
, Cristina Andres-Lacueva

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

Abstract

In this paper, a sensitive, precise, and selective analytical method has been developed for the identification and quantification of resveratrol metabolites in human low-density lipoprotein (IDL) after moderate consumption of red wine, using high-performance liquid chromatography electrospray in tandem mass spectrometry (LC-ESI-MS/ MS). From different extraction procedures tested, solid-phase extraction was selected to minimize matrix effects reaching the highest sensitivity. Standard calibration curves prepared in human LDL for trans-resveratrol were linear over a range of 0.44-438.59 pmol/mL. The accuracy and interassay precision of this LC-MS/MS assay for resveratrol showed a coefficient of variation of

Originalsprache	Englisch
Seiten (von - bis)	3149-3155
Seitenumfang	7
Fachzeitschrift	Analytical Chemistry
Jahrgang	77
Ausgabenummer	10
Publikationsstatus	Veröffentlicht - 2005

ÖFOS 2012

3012 Pharmazie, Pharmakologie, Toxikologie

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http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i10/abs/ac0484272.html

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Zitationsweisen

Urpi-Sarda, M., Jauregui, O., Lamuela-Raventos, R. M., Jäger, W., Böhmdorfer, M., Covas, M.-I., & Andres-Lacueva, C. (2005). Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Analytical Chemistry, 77(10), 3149-3155. http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i10/abs/ac0484272.html

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abstract = "In this paper, a sensitive, precise, and selective analytical method has been developed for the identification and quantification of resveratrol metabolites in human low-density lipoprotein (IDL) after moderate consumption of red wine, using high-performance liquid chromatography electrospray in tandem mass spectrometry (LC-ESI-MS/ MS). From different extraction procedures tested, solid-phase extraction was selected to minimize matrix effects reaching the highest sensitivity. Standard calibration curves prepared in human LDL for trans-resveratrol were linear over a range of 0.44-438.59 pmol/mL. The accuracy and interassay precision of this LC-MS/MS assay for resveratrol showed a coefficient of variation of",

author = "Mireia Urpi-Sarda and Olga Jauregui and Lamuela-Raventos, \{Rosa M.\} and Walter J{\"a}ger and Michaela B{\"o}hmdorfer and Maria-Isabel Covas and Cristina Andres-Lacueva",

note = "Zeitschrift: Analytical Chemistry DOI: 10.1021/ac0484272 Coden: ANCHA Affiliations: Nutrition and Food Science Department, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain; Scientific and Technical Services, University of Barcelona, 08028 Barcelona, Spain; Institute of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria; Unitat de Lipids i Epidemiologia Cardiovascular de l'Institut Municipal d'Investigacio Medica, Barcelona, Spain Source-File: MedPharmChemScopus\_iso.csv Import aus Scopus: 2-s2.0-18844372768 Importdatum: 22.11.2006 17:15:22 09.08.2007: Datenanforderung 1817 (Import Sachbearbeiter)",

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Urpi-Sarda, M, Jauregui, O, Lamuela-Raventos, RM, Jäger, W , Böhmdorfer, M, Covas, M-I & Andres-Lacueva, C 2005, 'Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry', Analytical Chemistry, Jg. 77, Nr. 10, S. 3149-3155. <http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i10/abs/ac0484272.html>

Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. / Urpi-Sarda, Mireia; Jauregui, Olga; Lamuela-Raventos, Rosa M. et al.
in: Analytical Chemistry, Band 77, Nr. 10, 2005, S. 3149-3155.

Veröffentlichungen: Beitrag in Fachzeitschrift › Artikel › Peer Reviewed

TY - JOUR

T1 - Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry

AU - Urpi-Sarda, Mireia

AU - Jauregui, Olga

AU - Lamuela-Raventos, Rosa M.

AU - Jäger, Walter

AU - Böhmdorfer, Michaela

AU - Covas, Maria-Isabel

AU - Andres-Lacueva, Cristina

N1 - Zeitschrift: Analytical Chemistry DOI: 10.1021/ac0484272 Coden: ANCHA Affiliations: Nutrition and Food Science Department, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain; Scientific and Technical Services, University of Barcelona, 08028 Barcelona, Spain; Institute of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria; Unitat de Lipids i Epidemiologia Cardiovascular de l'Institut Municipal d'Investigacio Medica, Barcelona, Spain Source-File: MedPharmChemScopus_iso.csv Import aus Scopus: 2-s2.0-18844372768 Importdatum: 22.11.2006 17:15:22 09.08.2007: Datenanforderung 1817 (Import Sachbearbeiter)

PY - 2005

Y1 - 2005

N2 - In this paper, a sensitive, precise, and selective analytical method has been developed for the identification and quantification of resveratrol metabolites in human low-density lipoprotein (IDL) after moderate consumption of red wine, using high-performance liquid chromatography electrospray in tandem mass spectrometry (LC-ESI-MS/ MS). From different extraction procedures tested, solid-phase extraction was selected to minimize matrix effects reaching the highest sensitivity. Standard calibration curves prepared in human LDL for trans-resveratrol were linear over a range of 0.44-438.59 pmol/mL. The accuracy and interassay precision of this LC-MS/MS assay for resveratrol showed a coefficient of variation of

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M3 - Article

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