TY - JOUR
T1 - Value of Rotational Thromboelastometry and Impedance Aggregometry for Evaluating Coagulation Disorders in Patients With Cyanotic and Nongenetic Congenital Heart Disease
AU - Pujol, Claudia
AU - Stöckl, Alexander
AU - Mebus, Siegrun
AU - Röschenthaler, Franz
AU - Holdenrieder, Stefan
AU - Ewert, Peter
AU - Nagdyman, Nicole
AU - Neidenbach, Rhoia C
AU - Kaemmerer, Harald
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - Adults with cyanotic congenital heart diseases (CCHD) have a higher risk for bleeding, but also for thrombosis. Rotational thromboelastometry (RT), using tissue factor (EXTEM), a contact activator (INTEM) or cytochalasin (FIBTEM), assesses coagulation by determining the time to initiation of clotting (CT) and clot firmness (MCF) including platelet-fibrin-interaction. The aim of this study was to evaluate RT and whole blood impedance aggregometry (IA) in CCHD compared with a control group without chronic cyanosis (NCCHD). These were used to establish normal reference ranges. We prospectively included 124 patients (76 CCHD, 48 NCCHD). Mean oxygen saturation in CCHD was 81.5%, and 98% in NCCHD (p
AB - Adults with cyanotic congenital heart diseases (CCHD) have a higher risk for bleeding, but also for thrombosis. Rotational thromboelastometry (RT), using tissue factor (EXTEM), a contact activator (INTEM) or cytochalasin (FIBTEM), assesses coagulation by determining the time to initiation of clotting (CT) and clot firmness (MCF) including platelet-fibrin-interaction. The aim of this study was to evaluate RT and whole blood impedance aggregometry (IA) in CCHD compared with a control group without chronic cyanosis (NCCHD). These were used to establish normal reference ranges. We prospectively included 124 patients (76 CCHD, 48 NCCHD). Mean oxygen saturation in CCHD was 81.5%, and 98% in NCCHD (p
KW - Adult
KW - Blood Coagulation/physiology
KW - Blood Coagulation Disorders/blood
KW - Cyanosis/blood
KW - Female
KW - Heart Defects, Congenital/blood
KW - Humans
KW - Male
KW - Middle Aged
KW - Platelet Aggregation/physiology
KW - Platelet Count
KW - Reproducibility of Results
KW - Thrombelastography/methods
KW - Young Adult
KW - PLATELET-AGGREGATION
KW - THROMBOSIS
UR - http://www.scopus.com/inward/record.url?scp=85062880914&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2019.02.031
DO - 10.1016/j.amjcard.2019.02.031
M3 - Article
C2 - 30885417
SN - 0002-9149
VL - 123
SP - 1696
EP - 1702
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 10
ER -