Description
Polyoxometalates (POMs), as early-transition-metal–oxygen coordination compounds, boast unprecedented structural versatility and unique properties. This adaptability renders POMs highly suitable for diverse biological applications, presenting avenues for drug delivery and cell-biological uptake studies involving biological effector molecules. Inspired by the superchaotropic behavior, this work identifies the first molecular membrane carriers of the all-inorganic Keggin POM anion type, functional in both model membranes and living cells. These carriers outperform established molecular carriers, transporting arginine-rich and lysine-rich oligo- and polypeptides. The findings encourage further optimization of POM carriers, presenting a paradigm shift in understanding and exploiting the biological functionality of these versatile compounds.Eight POMs, including representatives from globular Keggin and planar Anderson archetypes, were systematically tested, varying in charge status from ‒3 to ‒8. The correlation between their stability and speciation was meticulously analyzed. To counter hydrolysis issues, highly charged mixed-metal derivatives were included, showcasing stability at neutral pH. This screening process identified two compounds with both superchaotropic characteristics and remarkable stability for further transport experiments. Importantly, the stability and speciation studies are crucial in unravelling the intricate behaviour of POMs in aqueous solutions.
| Period | 28 Jul 2024 |
|---|---|
| Event title | 45th International Conference on Coordination Chemistry (ICCC 2024) |
| Event type | Conference |
| Location | Fort Collins, United States, ColoradoShow on map |
| Degree of Recognition | International |